从北美乳牛中分离出来的乳腺炎病原体的抗微生物敏感性,2011-2022年
Michael T Sweeney1, Lacie Gunnett1, Dipu Mohan Kumar1
1Zoetis, Kalamazoo, MI, USA.
Veterinary microbiology
|February 10, 2024
概括
在北美,常见的乳腺炎病原体,如菌根和大肠杆菌的抗菌耐药性仍然很低. 这项研究发现,乳牛在12年内持续存在低耐药水平,支持目前的管理实践.
科学领域:
- 兽医微生物学 兽医微生物学
- 抗微生物耐药性 抗微生物耐药性
- 乳牛的健康 乳牛的健康
背景情况:
- 乳腺炎是乳牛的重要经济和动物福利问题.
- 监测乳腺炎病原体的抗微生物敏感性对于有效的治疗和耐药性管理至关重要.
- 之前的调查表明耐药性较低,但需要持续监测.
研究的目的:
- 评估北美关键乳腺炎病原体的体外抗菌敏感性.
- 确定2011年至2022年抗菌素耐药性的趋势.
- 评估常见的抗微生物药物对乳腺炎控制的持续有效性.
主要方法:
- 从2011年至2022年收集了乳腺炎病例中的细菌分离物 (Streptococcus dysgalactiae,Streptococcus uberis,Staphylococcus aureus,Escherichia coli) 的细菌.
- 根据CLSI标准,使用微稀释进行了体外抗菌敏感性测试.
- 测试包括安皮西林,塞福拉,塞夫蒂奥弗,塞法洛丁,红素,西林,青素-新生物素和皮利米.
主要成果:
- 对所有病原体的大多数测试抗微生物药物观察到低耐药性.
- 具体的低耐药性例子包括S. dysgalactiae对青素-新生物素 (0%) 和ceftiofur (0.1%) 的耐药性.
- S. uberis对安皮西林 (0%) 和塞夫蒂奥夫尔 (0.2%) 的耐药性较低,而大肠杆菌对塞夫蒂奥夫尔 (2.8%) 和塞福拉 (3.4%) 的耐药性较低.
结论:
- 美国和加拿大的乳腺炎病原体在体外表现出持续较低的抗菌素耐药性.
- 在过去的12年里,敏感性没有发生实质性的变化.
- 目前的抗微生物药物在治疗乳腺炎方面仍然有效,即使长期使用.
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