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使用0.35 T MRI-Linac系统对质母细胞瘤进行动态对比增强MR perfusion协议的实施和评估

Danilo Maziero¹, Gregory Albert Azzam², Macarena de La Fuente³

¹Department of Radiation Medicine & Applied Sciences, UC San Diego Health, La Jolla, CA 92093, United States; Department of Radiation Oncology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL 33136, United States.

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)

|February 10, 2024

概括

这项研究展示了一种新的MRI协议,用于在放射治疗期间跟踪质母细胞瘤,使用0.35特斯拉MRI-Linac. 该方案成功评估了治疗反应,显示了改善患者监测的潜力.

科学领域:

辐射疗法辐射疗法
医疗成像医学成像
在瘤学瘤学.

背景情况:

磁力共振成像线性加速器 (MRI-Linac) 系统可以每天跟踪放射治疗 (RT) 期间的磁力共振成像变化.
开发通用0.35特斯拉 (T) MRI-Linac场强度的协议对于广泛采用至关重要.
评估质母细胞瘤对RT的反应需要强大的成像技术.

研究的目的:

在0.35 T MRI-Linac.上实施和验证对比后3D-T1加权 (3D-T1w) 和动态对比增强 (DCE) 的MRI协议.
评估使用该方案评估质母细胞瘤对RT的反应的可行性.
为了比较0.35T和3TMRI系统之间的图像质量和数据一致性.

主要方法:

获得了3D-T1w和DCE数据,来自一个流动幻体和两个质母细胞瘤患者,他们在0.35 T MRI-Linac上接受RT.
将0.35 T MRI-Linac 3D-T1w图像与用于对比度增强检测的3 T MRI图像进行比较.
在时间和空间上分析了DCE数据,在Pre RT,Mid RT和Post RT时间点推导出Ktrans地图.

主要成果:

在0.35T MRI-Linac和3T扫描仪之间,3D-T1w对比度增强体积是相似的.
DCE图像显示时间稳定性,Ktrans图与患者治疗结果相关.
Ktrans值显示响应者显著下降,非响应者略有增加.

结论:

开发的后对比3D-T1w和DCEMRI协议在0.35TMRI-Linac系统上是可行的.
该方案对监测质母细胞瘤对放射治疗的反应显示出希望.
这些发现支持MRI-Linac系统用于精确放射治疗的临床实用性.

关键词:

动态对比增强动态对比增强评估质母细胞瘤的反应.通过MRI-Linac进行核磁共振.在MRI指导的RT中,RT是指导的.

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Magnetic Resonance Imaging

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