在帕金森病中,大脑结构网络的拓变化与冷漠
Shaoyun Ge1, Jun Liu1, Yongfeng Jia1
1Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China.
Brain research bulletin
|February 10, 2024
概括
帕金森病 (PD) 中的冷漠性显示出优化的全球大脑网络拓,但破坏了区域组织,特别是在前-状-边缘电路中. 这些网络变化可能解释了PD患者无动于衷的神经机制.
科学领域:
- 神经科学是一个神经科学.
- 神经学 神经学
- 医疗成像医学成像
背景情况:
- 漠不关心是帕金森病 (PD) 的常见神经心理症状之一.
- 在PD中无动于衷的潜在神经网络机制仍然不清楚.
- 调查PD与冷漠的脑结构网络改变至关重要.
研究的目的:
- 检查帕金森病患者对大脑结构网络的拓变化.
- 确定与PD无动于衷相关的特定大脑区域和网络属性.
主要方法:
- 采用扩散张力成像 (DTI) 和图形理论分析.
- 与47名无情PD (aPD) 患者,37名非无情PD (naPD) 患者和40名健康对照 (HC) 进行了比较.
- 分析了白质 (WM) 结构网络的全球和区域拓性质.
主要成果:
- 与无情的PD患者相比,无情的PD患者的全球聚类系数 (Cp) 增加.
- 在aPD患者中观察到区域结节性质的减少,特别是在右背侧前额叶皮质 (DLPFC),右尾状核 (CAU),右海马和右上顶顶圈.
- 漠不关心度 (AS) 评分与PD患者的右DLPFC和右CAU的中心度有负相关.
结论:
- 帕金森病中的冷漠与优化的全球大脑网络拓学有关,但破坏了区域网络组织.
- 这些发现凸显了前-上-边缘电路在PD无动感的神经机制中的参与.
- 特定大脑区域的变化拓性质可能为aPD无动于衷的病理生理学提供了见解.
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