在自闭症中全脑结构连接体不对称
Seulki Yoo1, Yurim Jang2, Seok-Jun Hong3
1Convergence Research Institute, Sungkyunkwan University, Suwon, Republic of Korea.
NeuroImage
|February 10, 2024
概括
自闭症谱系障碍 (ASD) 显示出不典型的大脑结构不对称性,特别是在感官和默认模式区域的右侧不对称性较弱. 这种连接体不对称可能有助于预测自闭症症状和智力.
科学领域:
- 神经科学是一个神经科学.
- 发育神经科学的发展神经科学.
- 脑部成像 脑部成像
背景情况:
- 自闭症谱系障碍 (ASD) 是一种影响社会和感官技能的神经发育状况.
- 众所周知,ASD中的大脑形态不对称,但结构连接组组织中的半球差异尚未得到充分研究.
研究的目的:
- 研究ASD患者的全脑结构连接不对称性.
- 通过网络通信分析,探索这些不对称性的拓基础.
- 评估结构连接体不对称性的潜力,作为ASD相关症状的预测措施.
主要方法:
- 利用自闭症脑成像数据交换 (ABIDE) 倡议的扩散磁共振成像数据.
- 应用了减小维度的技术,以创建结构连接的低维表示.
- 计算了不对称性指数,并分析了网络通信效率和导航.
主要成果:
- 在ASD患者的感官和默认模式区域中确定了非典型的结构连接体不对称性,与右半球相对的不对称性减少.
- 观察到全球网络通信效率下降和特定大脑区域的网络导航受损 (下皮质,边缘皮质,前侧皮质,侧侧视觉皮质).
- 监督机器学习模型表明,连接组不对称性可以预测ASD的沟通障碍和非语言智力.
结论:
- 在自闭症谱系障碍中,结构连接体不对称性发生变化,特别是在感官和默认模式网络中.
- 特定地区的网络通信缺陷与观察到的连接组不对称性相关.
- 连接体不对称性是预测ASD临床特征的潜在生物标志物.
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