碳氧甲基土豆粉水凝封装环氧烯金属有机框架,用于S-纳普罗的反选择性加载及其编程释放
Guodong Zhang1, Zheng-Zhi Yin2, Xiaoming Zuo3
1Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology, School of Petrochemical Engineering, Changzhou University, Changzhou 213164, China.
International journal of biological macromolecules
|February 10, 2024
概括
一个新型的环氧金属有机框架 (CD-MOF) 选择性地加载S-naproxen (S-NPX). 这种装有S-NPX的CD-MOF嵌入于碳糖甲基土豆粉水凝中,可以通过pH和谷胺触发受控释放.
科学领域:
- 材料科学 材料科学 材料科学
- 药物运输 药物运输 药物运输
- 纳米技术纳米技术
背景情况:
- 奇拉性药物反体表现出不同的药理活性.
- 开发选择性药物递送系统对于性化合物至关重要.
- 自然的多糖为药物封装提供生物相容的平台.
研究的目的:
- 开发一种以天然多糖为基础的载体,用于对S-纳普罗进行反选择性加载和编程释放.
- 为了研究循环德克斯特林金属有机框架 (CD-MOF) 的合成和特性,用于治疗治疗药物.
- 探索从开发的水凝系统中释放S-naproxen的动力学和机制.
主要方法:
- 通过K+与γ-cyclodextrin的协调合成CD-MOF.
- 在CD-MOF上对S-naproxen (S-NPX) 的酶选择性加载,通过热力学计算得到证实.
- 在CD-MOF-S-NPX上植入二硫化物键 (-S-S-) 以防水性.
- 封装装载有S-NPX的CD-MOF在碳糖甲基土豆粉 (CPS) 水凝中.
- 研究由pH诱导的水凝膨胀和GSH诱导的CD-MOF崩引发的编程释放.
- 使用希古奇模型分析释放动力学.
主要成果:
- 在CD-MOF中,S-NPX比R-naproxen具有优越的结合和负载.
- 合成的载体在对轻微的基本pH (∼pH 8.0) 和谷氨 (GSH) 的反应中表现出S-NPX的受控释放.
- 释放动力学遵循希古奇模型,表明扩散控制释放.
结论:
- 使用CD-MOF建立了一种简单有效的方法,用于使用S-naproxen进行enantioselective加载.
- 开发的基于多糖的水凝系统允许对S-NPX的编程和刺激反应释放.
- 这项研究为使用天然多糖和MOFs的奇拉药物递送系统提出了一个有希望的策略.
相关概念视频
01:05Bioavailability Enhancement: Drug Stability Enhancement and GI Retention
Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
01:19Modified-Release Drug Delivery Systems: Rate-Programmed II
Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
01:22Modified-Release Drug Delivery Systems: Rate-Programmed I
Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
01:30Modified-Release Drug Delivery Systems: Stimuli-Activated
Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...
01:24Site-Targeted Drug Delivery Systems: Polymeric Carriers
Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
01:11Oral Drug Delivery Systems: Delayed-Release Systems
Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...