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生物医学中的纳米晶技术:从实验室到诊所

Ekta Pardhi¹, Ravindra Vasave¹, Vaibhavi Srivastava¹

¹Pharmaceutical Nanotechnology Research Laboratory, Department of Pharmaceutics, National Institute of Pharmaceutical Education and Research, Hyderabad, Telangana, India.

Drug discovery today

|February 10, 2024

概括

药物纳米晶体提供无载体的解决方案,以提高溶解性和溶解性不佳的药物,解决主要的药物开发挑战,并为新的治疗选择铺平道路.

科学领域:

制药科学制药科学
纳米技术纳米技术
药物运输药物运输药物运输

背景情况:

不断上升的研发成本和水溶性不佳阻碍了药物开发.
生物制药分类系统 (BCS) 的II和IV类药物面临着重大溶解性挑战.
专利到期需要新的药物开发方法.

研究的目的:

提供药物纳米晶技术的全面审查.
探索提高难溶性药物的可溶性和溶解率的策略.
讨论纳米晶体在克服制药开发障碍方面的潜力.

主要方法:

关于药物纳米晶体制备和表征的科学文献的综述.
对纳米晶体配方稳定剂选择标准的分析.
检查各种纳米晶体制造技术.
对纳米晶体的先进表征方法的评估.

主要成果:

纳米晶体代表了一个有前途的纳米技术驱动的,无载体的合体药物递送系统.
有各种策略和稳定剂可用于增强药物的溶解性和溶解性.
先进的表征技术对于理解纳米晶体特性至关重要.
纳米晶格景观包括不断发展的技术,市场选择和临床前景.

结论:

药物纳米晶是一种可行的策略,用于解决药物开发中的可溶性和溶解性问题.
这项技术为克服研发成本和专利限制提供了一条途径.
纳米晶具有重塑未来制药市场和临床应用的巨大潜力.

关键词:

应用程序应用程序应用程序生物可用性生物可用性标志性特征的描述.纳米晶体是一种纳米晶体.准备准备准备准备稳定器稳定器稳定器

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