在单个活产儿中,母亲的甲状腺功能与葡萄糖代谢之间是否存在双向关联? 一个出生队列研究研究
Jingru Lu1, Linlin Zhu1, Yufan Guo1
1School of Public Health, Anhui Medical University, No 81 Meishan Road, Hefei 230032, Anhui, China; Key Laboratory of Population Health Across Life Cycle (Anhui Medical University), Ministry of Education of the People's Republic of China, No 81 Meishan Road, Hefei 230032, Anhui, China; NHC Key Laboratory of Study on Abnormal Gametes and Reproductive Tract, No 81 Meishan Road, Hefei 230032, Anhui, China; Anhui Provincial Key Laboratory of Environment and Population Health Across the Life Course, No 81 Meishan Road, Hefei 230032, Anhui, China.
孕妇的甲状腺功能,特别是自由甲状腺素 (FT4) 和甲状腺刺激激素 (TSH),会影响孕妇的葡萄糖代谢. 这些甲状腺激素会影响怀孕早期和中期的禁食血葡萄糖 (FPG) 水平.
科学领域:
- 内分泌学 在内分泌学.
- 孕产妇和胎儿医学 孕产妇和胎儿医学
- 代谢障碍 代谢障碍 代谢障碍
背景情况:
- 孕妇的甲状腺功能对于妊娠的结果至关重要.
- 怀孕期间葡萄糖代谢的改变会导致诸如妊娠期糖尿病等并发症.
- 了解甲状腺激素和葡萄糖调节之间的相互作用对于产前护理至关重要.
研究的目的:
- 研究孕妇甲状腺功能标志物与整个怀孕期间葡萄糖代谢之间的关联.
- 探索甲状腺激素和禁食血葡萄糖 (FPG) 之间的潜在双向关系.
主要方法:
- 追溯分析了2375名马安山出生队列中的孕妇的数据.
- 测量母亲的甲状腺刺激激素 (TSH),自由甲状腺素 (FT4),甲状腺过氧化酶抗体 (TPOAb) 和第一,第二和第三季度的FPG.
- 应用交叉滞后面板模型来评估时间关联.
主要成果:
- 自由甲状腺素 (FT4) 显示了第一季度与FPG的正相关性,第二季度的负相关性.
- 甲状腺刺激激素 (TSH) 与第二个三个月的FPG有负面关联.
- 第一个三个月的TSH积极预测了第二个月的FPG;对于TPOAb和FPG没有发现显著的关联.
结论:
- 孕妇的甲状腺功能和葡萄糖代谢在怀孕期间表现出非双向的关联.
- FT4和TSH水平显著影响FPG度,特别是在第一和第二个三个月.
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