相关实验视频
Updated: Jul 3, 2025

09:03
Manufacture and Drug Delivery Applications of Silk Nanoparticles
Published on: October 8, 2016
15.8K
对于天然产品及其应用的新型纳米药物输送系统
Li Huang1, Xue-Hua Huang1, Xi Yang1
1State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, China.
Pharmacological research
|February 10, 2024
概括
新型纳米药物递送系统 (NDDS) 通过克服溶解性和生物可用性问题来增强天然产品药物开发. 这些先进的配方提高了治疗效率,并扩大了天然产品的应用范围.
科学领域:
- 制药科学 制药科学
- 自然产品化学 自然产品化学
- 纳米技术 纳米技术
背景情况:
- 自然产品具有治疗潜力,但面临着难以溶解性和有限的生物利用性等挑战.
- 这些限制阻碍了天然产品在药物开发中的广泛应用.
- 先进的制药配方对于克服这些障碍至关重要.
研究的目的:
- 对天然产品的新型纳米药物输送系统 (NDDS) 进行审查和更新.
- 突出NDDS在提高自然化合物的治疗效率方面的潜力.
- 解决传统天然产品配方的局限性.
主要方法:
- 对自然产品纳米药物输送系统的最新文献的审查.
- 各种NDDS的分类,包括纳米悬浮,纳米脂质体,,微乳液,纳米囊和固体脂质纳米颗粒.
- 分析表明改善溶解度,生物可用性和组织分布的研究.
主要成果:
- 对天然产品开发了各种NDDS,显示出显著的改进.
- 纳米悬浮,纳米脂质体,体和其他系统提高了溶解性和生物可用性.
- 这些系统还改善了自然化合物的组织分布,保留和透.
结论:
- 纳米药物输送系统为克服天然产品的局限性提供了一个有希望的方法.
- NDDS显著提高了基于天然产品的药物的治疗效率和适用性.
- 进一步开发和应用NDDS对于推动天然产品药物发现至关重要.
相关概念视频
Drug Delivery: Overview
294
The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
294
Factors Affecting Dissolution: Particle Size and Effective Surface Area
846
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
846
Drug Delivery: Miscellaneous Routes
340
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection, and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
340
Drug Delivery: Enteral Route
451
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
451
Drug Discovery: Overview
7.9K
Drug discovery is a multifaceted process involving extensive screening, testing, and optimization of lead compounds to identify potential new drugs for therapeutic use. It combines several approaches, including screening large numbers of natural products, chemical modification of known active molecules, identification of new drug targets, and rational design based on biological mechanisms and drug-receptor structure. These approaches are carried out in both academic research laboratories and...
7.9K

