Li Huang1, Xue-Hua Huang1, Xi Yang1

  • 1State Key Laboratory of Quality Research in Chinese Medicines, Macau University of Science and Technology, Macau, China.

Pharmacological research
|February 10, 2024
PubMed
概括

新型纳米药物递送系统 (NDDS) 通过克服溶解性和生物可用性问题来增强天然产品药物开发. 这些先进的配方提高了治疗效率,并扩大了天然产品的应用范围.

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Drug Delivery: Overview

The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
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Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
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Transdermal patches transport drugs...
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