在出生时体重非常低的婴儿中,产前胰岛素耐药性:一项前性研究
Itay Zamir1, Elisabeth Stoltz Sjöström2, Johannes van den Berg3
1Department of Clinical Sciences, Pediatrics, Umeå University, Umeå, Sweden itay.zamir@umu.se.
出生时体重非常低的婴儿表现出胰岛素抵抗的荷尔蒙症状. 较低的妊娠年龄和高血糖与这些脆弱的婴儿的胰岛素抵抗标志物增加有关.
科学领域:
- 新生儿内分泌学 新生儿内分泌学
- 在早产婴儿的代谢障碍.
背景情况:
- 非常低出生体重 (VLBW) 的婴儿经常经历葡萄糖失调.
- 了解荷尔蒙特征对于管理早产新生儿代谢并发症至关重要.
研究的目的:
- 为了研究VLBW婴儿的葡萄糖相关激素特征.
- 确定新生儿高血糖和住院期间胰岛素抵抗之间的关联.
主要方法:
- 在瑞典新生儿单位对48名VLBW婴儿进行前性观察研究.
- 测量了血激素度 (胰岛素,C-,格林,GLP-1,葡萄糖素,瘦素,抵抗素,亲胰岛素) 和计算的胰岛素抵抗指数 (HOMA2,QUICKI) 在DOL 7周和36周PMA.
- 分析了妊娠年龄,高血糖和荷尔蒙标志物之间的关联.
主要成果:
- 较低的妊娠年龄与较高的葡萄糖,胰岛素,C-,亲胰岛素,勒,格林,抵抗素,GLP-1相关,增加了HOMA2,降低了QUICKI,以及较低的亲胰岛素:胰岛素比率.
- 与正常血糖的婴儿相比,高血糖的婴儿表现出较高的葡萄糖,C-,胰岛素,瘦素,亲胰岛素和较低的QUICKI.
- 在DOL 7上升的葡萄糖和亲胰岛素,以及更高的胰岛素:C比和更低的QUICKI,预测高血糖持续时间更长.
结论:
- VLBW婴儿表现出一种暗示胰岛素抵抗的荷尔蒙特征.
- 诸如较低的妊娠年龄和高血糖等因素与VLBW婴儿的胰岛素抵抗标志物升高有显著联系.
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