介质干细胞和瘤细胞之间的信号交叉:对瘤抑制或进展的影响
Mojtaba Taheri1, Hossein Abdul Tehrani1, Sadegh Dehghani2
1Department of Medical Biotechnology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Cytokine & growth factor reviews
|February 10, 2024
概括
介酶干细胞 (MSC) 在癌症中表现出双重作用,既起瘤抑制作用,又起瘤促进作用. 了解这些复杂的生物特性对于基于MSC的安全有效的癌症疗法至关重要.
科学领域:
- 生物医学科学 生物医学科学
- 癌症研究 癌症研究
- 干细胞生物学 干细胞生物学
背景情况:
- 介质细胞干细胞 (MSC) 由于其差异化潜力和免疫逃避性质,被广泛用于再生医学和癌症治疗.
- MSCs表现出瘤热带性,并具有可以影响瘤发育的固有特性,这导致它们在各种治疗策略中受到调查.
- 尽管有希望的特征,但相互矛盾的报道强调MSCs在癌症中的瘤抑制和瘤支持作用,强调它们复杂的生物性质.
研究的目的:
- 在过去二十年中审查MSC和癌症的临床前研究.
- 阐明MSC的瘤抑制和瘤支持功能的机制.
- 确定关键的细胞通路,以提高MSC基础的癌症治疗的安全性和有效性.
主要方法:
- 关于介质干细胞和癌症的临床前研究的全面审查.
- 对研究MSC特性,瘤进展和细胞机制的研究进行分析.
- 确定未来治疗向的关键途径.
主要成果:
- 介酶干细胞 (MSCs) 在癌症中表现出复杂的,取决于背景的作用,表现出瘤抑制和瘤支持的特征.
- MSCs的双重功能归因于它们在瘤微环境中的动态生物特性和相互作用.
- 临床前证据表明,MSCs可以根据各种因素抑制或促进瘤生长和转移.
结论:
- 癌症中MSCs的多方面的性质需要在临床前和临床研究中仔细考虑其生物特性.
- 了解MSCs支持和抗瘤作用的复杂机制对于开发基于MSC的安全有效的癌症治疗至关重要.
- 针对涉及MSC与癌症相互作用的特定细胞通路,有望优化未来的治疗策略并改善患者的治疗结果.
更多相关视频
09:30Mesenchymal Stem Cell Isolation from Pulp Tissue and Co-Culture with Cancer Cells to Study Their Interactions
Published on: January 7, 2019
10.3K
07:44Studying the Effects of Tumor-Secreted Paracrine Ligands on Macrophage Activation using Co-Culture with Permeable Membrane Supports
Published on: November 28, 2019
7.5K
相关概念视频
Mesenchymal Stem Cells
4.7K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
4.7K
The Tumor Microenvironment
6.6K
Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
6.6K
Cancer Stem Cells and Tumor Maintenance
4.9K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
4.9K
Interactions Between Signaling Pathways
6.3K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.3K
Metastasis
5.5K
Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
5.5K
mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K
