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Updated: Jul 3, 2025

In Vitro Analysis of E3 Ubiquitin Ligase Function
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结构导向工程通过UBE2E1实现了E3无酶和多功能的蛋白质无处不在通过UBE2E1实现

Xiangwei Wu1,2, Yunxiang Du1, Lu-Jun Liang3

  • 1New Cornerstone Science Laboratory, Tsinghua-Peking Joint Center for Life Sciences, MOE Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Center for Synthetic and Systems Biology, Department of Chemistry, Tsinghua University, Beijing, 100084, China.

Nature communications
|February 10, 2024
PubMed
概括

科学家们使用UBE2E1酶发现了一种无E3的泛化机制. 这一突破使定制的蛋白质无化成为可能,推动了细胞过程和蛋白质功能的研究.

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