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Updated: Jul 3, 2025

Assessing Tumor Microenvironment of Metastasis Doorway-Mediated Vascular Permeability Associated with Cancer Cell Dissemination using Intravital Imaging and Fixed Tissue Analysis
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癌细胞侵入性的细胞间转移通过内体介导的蛋白酶分离

Eva Maria Wenzel1,2, Nina Marie Pedersen1,2, Liv Anker Elfmark1,2

  • 1Centre for Cancer Cell Reprogramming, Faculty of Medicine, University of Oslo, Oslo, Norway.

Nature communications
|February 10, 2024
PubMed
概括

癌细胞可以通过MT1-MMP (矩阵金属蛋白酶14) 的可溶性片段将侵入性转移到非侵入性细胞. 这种转移是由酸性内体内TKS4/5蛋白质调解的,促进癌细胞的入侵.

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