暴露于二-2-乙基基甲酸盐 (DEHP) 会增加患癌症的风险
Luchen Yang1, Xiaoyang Liu1, Zhufeng Peng1
1Department of Urology, Institute of Urology, West China Hospital of Sichuan University, No. 37, Guoxue Lane, Wuhou District, Chengdu, 610041, China.
BMC public health
|February 10, 2024
概括
暴露于常见的塑化剂二二乙基甲酸盐 (DEHP) 与癌症风险增加有关. 在美国的一项大型人口研究中,在各种癌症类型,特别是生殖系统癌症中观察到这种关联.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 癌症流行病学 癌症流行病学
背景情况:
- 癌症对全球健康和经济构成重大挑战.
- 环境中有毒物质,如二二甲基甲酸 (DEHP) 在癌症发展中的作用尚不清楚.
- DEHP是一种广泛使用的塑化剂,在环境中无处不在.
研究的目的:
- 调查暴露于二-2-乙烯) 甲酸盐 (DEHP) 和癌症患病率之间的潜在关联.
- 分析与癌症风险相关的DEHP代谢物度.
- 为了探索与DEHP暴露相关的特定癌症类型.
主要方法:
- 利用了2011-2018年国家健康和营养检查调查 (NHANES) 的数据 (n=6147).
- 采用多重后勤回归来评估DEHP代谢物与癌症之间的关联.
- 按年龄和性别进行了分层分析,并按四分位数分析了DEHP度.
主要成果:
- 在DEHP暴露和癌症患病率增加之间发现了显著的关联,代谢物表现出类似的趋势 (OR > 1.0,p < 0.05).
- 在调整混因素后,这种关联仍然存在,并且在各个年龄层和性别层中保持显著.
- 特别值得注意的是,DEHP暴露与女性生殖系统癌症,男性生殖系统癌症和其他癌症的更高风险有关,但不是皮肤和软组织癌症.
结论:
- 暴露于二-2-乙烯基) 甲酸盐 (DEHP) 与患癌症的风险显著增加有关.
- 女性和男性的生殖系统癌症,以及其他未指定的癌症,显然与DEHP暴露有关.
- 对DEHP的致癌机制和公共卫生影响的进一步研究是有必要的.
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