在抗病毒治疗期间,慢性乙型肝炎患者的功能
Nerma Čustović1, Lejla Alić2, Ismar Rašić3
1Clinic for Gastroenterology and Hepatology, Clinical Centre of the University of Sarajevo, Sarajevo, Bosnia and Herzegovina.
概括
慢性乙型肝炎 (CHB) 治疗的特诺福维尔二松胺 (TDF) 治疗显示出良好的安全性. 长期使用TDF的抗病毒疗法对CHB患者的功能没有显著影响.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 腎臟病學 (nephrology) 是一種醫學.
- 药理学 药理学是指药理学的学科.
背景情况:
- 慢性乙型肝炎 (CHB) 的管理通常涉及长期的抗病毒治疗.
- 诺福维尔二醇烟酸 (TDF) 是一种常用的抗病毒药物,用于治疗CHB.
- 评估TDF的长期安全性对于患者管理至关重要.
研究的目的:
- 分析用二二醇烟酸 (TDF) 治疗抗病毒药物的持续时间对CHB患者功能的影响.
- 为了评估不同持续时间接受TDF治疗的CHB患者的功能参数.
主要方法:
- 75名CHB患者的横截面研究,基线功能正常,接受TDF治疗.
- 通过使用MDRD公式估计的膜过率 (eGFR) 来评估功能.
- 测量了血清肌素,24小时尿蛋白分泌量,HBV-DNA病毒载量,APRI和FIB-4分数.
主要成果:
- 治疗时间 ≤2年 (n=37) 和 >2年 (n=38) 的患者之间平均eGFR没有显著差异.
- 血清肌素和24小时尿蛋白分泌量在两组之间没有显著差异.
- 在参数和病毒载量,APRI或FIB-4得分之间没有发现显著的相关性.
结论:
- 在CHB患者中,TDF抗病毒治疗的持续时间并没有显著改变测量的功能参数.
- 在慢性乙型肝炎患者中,TDF表现出良好的安全性,即使治疗持续时间长.
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