结交性表观遗传调节剂,MEDEA和DEMETER,协同抑制了Arabidopsis中的子宫外芽的形成
Mohit P Rajabhoj1, Sudev Sankar1,2, Ramesh Bondada1
1School of Biology, IISER Thiruvananthapuram, Thiruvananthapuram, Kerala, 695551, India.
Plant cell reports
|February 11, 2024
概括
表观遗传调节剂MEDEA (MEA) 和DEMETER (DME) 控制植物的发展. 胞细胞中MEA和DME功能的丧失导致子宫外发芽体,揭示了它们在限制体活动中的作用.
科学领域:
- 植物生物学 植物生物学
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 发育生物学是发展生物学.
背景情况:
- 植物的生命周期涉及到代代的交替,其中从细胞体转变为细胞体转变至关重要.
- 众所周知,表观遗传调节剂DEMETER (DME) 和MEDEA (MEA) 能够控制Arabidopsis.com中的体细胞生长.
- 对于DME和MEA的衰退性同卵性突变通常是致命的,防止在胞细胞中进行研究.
研究的目的:
- 调查DME和MEA在菌体发育中的作用.
- 了解MEA和DME超越游戏生成的协同功能.
- 阐明这些监管者控制射击峰发展的机制.
主要方法:
- 使用CENH3-哈普洛伊德诱导体对突变基因的父传输来产生可活的mea-1;dme-2胞.
- 进行了染色体免疫沉 (ChIP),DNA甲基化和基因表达分析.
- 采用RNA干扰 (RNAi) 来降低特定的射击促进因素.
主要成果:
- 同时丧失MEA和DME功能导致子宫外发芽在发芽顶部的美里系统.
- 发现MEA和DME在拍摄顶部表达,并调节拍摄促进因素.
- 使用RNAi对STM,CUC2和PLT5的下调部分挽救了双胞胎植物表型.
结论:
- MEA和DME在菌发育过程中在射出顶部限制系统活动方面发挥了协同作用.
- 这些表观遗传调节者控制关键射击发育因素的基因表达.
- 这些发现揭示了MEA和DME在植物发育中的新功能,将其影响力从雌同体到胞体阶段扩展.
更多相关视频
相关概念视频
01:09Epistasis Analysis
5.0K
Although Mendel chose seven unrelated traits in peas to study gene segregation, most traits involve multiple gene interactions that create a spectrum of phenotypes. When the interaction of various genes or alleles at different locations influences a phenotype, this is called epistasis. Epistasis often involves one gene masking or interfering with the expression of another (antagonistic epistasis). Epistasis often occurs when different genes are part of the same biochemical pathway. The...
5.0K
01:46Epigenetic Regulation
31.1K
Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
31.1K
01:52Eukaryotic Transcription Inhibitors
9.8K
Certain biochemical processes, such as embryonic development and cell growth regulation, depend on the repression of specific genes. DNA binding proteins known as eukaryotic transcription inhibitors regulate the repression of gene expression in eukaryotes. The presence of these inhibitors at the required location and time in the cell is triggered by the presence of hormones and additional signals from other cells.
Eukaryotic transcription inhibitors usually contain two distinct domains, a...
Eukaryotic transcription inhibitors usually contain two distinct domains, a...
9.8K
02:23Master Transcription Regulators
6.9K
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
6.9K
01:39Epistasis
46.8K
In addition to multiple alleles at the same locus influencing traits, numerous genes or alleles at different locations may interact and influence phenotypes in a phenomenon called epistasis. For example, rabbit fur can be black or brown depending on whether the animal is homozygous dominant or heterozygous at a TYRP1 locus. However, if the rabbit is also homozygous recessive at a locus on the tyrosinase gene (TYR), it will have an unshaded coat that appears white, regardless of its TYRP1...
46.8K
02:30Genomic Imprinting and Inheritance
34.4K
Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
The expression of some genes depends on which parent passed the gene to the offspring, through a phenomenon known as...
34.4K