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骨髓炎预测COVID-19患者的短期死亡率:一个多中心分析

Alexey Surov¹, Hans Jonas Meyer², Constantin Ehrengut²

¹Department of Radiology, Neuroradiology and Nuclear Medicine, Johannes Wesling Medical Center, Ruhr University Bochum, Germany.

Nutrition (Burbank, Los Angeles County, Calif.)

|February 11, 2024

概括

骨肌肉密度,特别是骨髓病,是COVID-19患者30天死亡率的强有力的预测因素. 在这些患者中识别骨髓炎,可以帮助识别那些风险更高的人.

科学领域:

放射学放射学是一门学科.
肺部病理学肺部病理学
关键护理医学关键护理医学

背景情况:

通过计算机断层扫描 (CT) 评估的身体组成可以预测COVID-19患者的预后.
此前关于这个主题的研究受到小样本大小的限制.
需要多中心验证来确认预后相关性.

研究的目的:

调查胸部CT的骨肌肉参数对预测COVID-19患者30天死亡率的预后相关性.
分析骨肌的面积和密度作为死亡率的预测指标.
在多中心环境中验证发现.

主要方法:

来自三个中心的临床数据库的回顾性分析 (2020-2022).
包括447名COVID-19患者 (142名女性,平均年龄63.8岁).
骨肌面积和密度测量在T12水平的胸部CT.

主要成果:

总体30天死亡率为26.3% (118名患者).
幸存者的骨肌密度明显高于非幸存者的骨肌密度 (25.8 vs 20.1 HU,P < 0.0001).
骨髓炎独立预测了30天的死亡率 (OR = 2.72,P = 0.0001).

结论:

骨髓瘤,骨肌肉脂肪透的标志物,与COVID-19患者的30天死亡率密切相关.
患有COVID-19且表现出骨髓炎的患者应被确定为高危人群.
胸部CT-derived骨肌的参数提供了有价值的预后信息.

关键词:

在 COVID-19 疫情中,这就是为什么CTCTCTCTCTCT 骨髓骨质炎 (Myosteatosis) 是一种骨髓骨质的疾病.萨尔科佩尼亚是什么意思萨尔科佩尼亚骨架肌肉是一个骨肌肉.

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