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热应激通过加剧2型糖尿病小鼠的线粒体损伤来减少棕色脂肪组织的活动

Penghua Lai¹, Linlin Zhang², Yan Qiu²

¹School of Medicine, Xiamen University, Xiamen, 361102, Fujian Province, China; School of Traditional Chinese Medicine, Xiamen University, Malaysia.

Journal of thermal biology

|February 11, 2024

概括

高温在2型糖尿病 (T2DM) 中恶化葡萄糖和脂质代谢,通过减少棕色脂肪组织 (BAT) 活动和线粒体功能. 这可能与T2DM小鼠在热应激下分支链氨基酸的积累有关.

科学领域:

代谢研究的研究.
内分泌学在内分泌学.
环境健康环境健康

背景情况:

2型糖尿病 (T2DM) 患者对高温的敏感性增加.
棕色脂肪组织 (BAT) 活动与T2DM有关,冷暴露改善了它.
热应力对T2DM中BAT活动的影响尚不清楚.

研究的目的:

研究热应激对T2DM小鼠葡萄糖和脂质代谢的影响.
确定热应力是否影响T2DM中的BAT活动.
探索热应力对T2DM中BAT影响的潜在机制.

主要方法:

一个T2DM小鼠模型被诱导使用高脂肪饮食和 estreptozotocin (STZ).
小鼠被暴露在热应激中3天.
评估了葡萄糖/脂质代谢,BAT活性 (qRT-PCR,电子显微镜,PET CT),并进行了BAT代谢 (UHPLC-Q-TOF MS).

主要成果:

在T2DM小鼠中,热应激加剧了葡萄糖和脂质代谢失调.
在BAT中,线粒体功能障碍因热应激而加剧.
在热应力下的T2DM小鼠中,BAT活性降低,可能是由于BCAA积累.

结论:

热应激对T2DM中BAT活动和线粒体功能产生负面影响.
在热应激下T2DM中恶化的代谢失调可能与BAT线粒体中异常的BCAA积累有关.

关键词:

分支链氨基酸分支链氨基酸.棕色脂肪组织的脂肪组织.热应激是一种热应激.2 型糖尿病 2 型糖尿病

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