与癌症检测和向治疗的免疫检查点相结合的aptamers:一篇评论
Yihan Li1, Weidong Liu1, Hongjuan Xu2
1NHC Key Laboratory of Carcinogenesis, Department of Neurosurgery, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China; The Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, School of Basic Medical Science, Central South University, Changsha, Hunan 410078, China.
International journal of biological macromolecules
|February 11, 2024
概括
阿普塔默为癌症监测和通过准免疫检查点来改善免疫疗法提供了一个有前途的工具. 本综述探讨了在癌症诊断和治疗中aptamer的应用,以提高抗瘤效率.
科学领域:
- 生物技术是生物技术.
- 免疫学 免疫学 免疫学
- 在瘤学瘤学.
背景情况:
- 免疫疗法,特别是免疫检查点封锁,是癌症治疗的关键方法.
- 由于患者异质性和复杂的瘤微环境 (TME),预测治疗疗效具有挑战性.
研究的目的:
- 审查癌症诊断和免疫治疗中对体的当前研究.
- 突出阿普坦体在准免疫检查点中的作用,以增强抗瘤效果.
- 讨论以aptamer为基础的癌症治疗的未来方向.
主要方法:
- 审查关于阿普坦和癌症免疫治疗的现有文献.
- 专注于针对免疫检查点的aptamers及其应用.
- 分析阿普坦特异性,亲和力和诊断/治疗潜力.
主要成果:
- 阿普塔默对癌症标具有很高的特异性和亲和力.
- 胺可以监测免疫系统和TME变化.
- 胺剂促进向免疫疗法和免疫检查点封锁.
结论:
- 胺剂是癌症诊断和监测的宝贵工具.
- 基于Aptamer的策略可以提高免疫治疗的疗效.
- 进一步研究以阿普坦为基础的免疫检查点疗法对阻止瘤免疫逃逸具有重大前景.
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