通过热响应的Janus纳米凝进行双重药物递送,以改善细胞吸收,持续释放和组合化疗-热疗法
Sakine Shirvalilou1, Samideh Khoei1, Sepideh Khoee2
1Finetech in Medicine Research Center, Iran University of Medical Sciences, Tehran, Iran; Department of Medical Physics, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
International journal of pharmaceutics
|February 11, 2024
概括
当与磁性高温症相结合时,装载有5-甲和Quercetin的Janus磁性纳米粒子增强了癌细胞死亡. 这种双重的药物输送和热敏化平台显示了癌症治疗的协同效应.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术 纳米技术
- 癌症治疗 癌症治疗
背景情况:
- 有针对性的药物输送系统对于提高癌症治疗疗效至关重要.
- 磁纳米粒子提供了局部药物释放和高热的潜力.
- 詹努斯磁纳米粒子 (JMNPs) 为双重药物输送和热敏化提供了一个新的平台.
研究的目的:
- 评估JMNP作为C6 (癌症) 和OLN-93 (正常) 细胞系中5-甲 (5-Fu) 和Quercetin (Qu) 的载体.
- 为了研究JMNPs与磁热过热结合的热敏化作用.
- 评估这种双药,热敏系统的协同治疗潜力.
主要方法:
- 使用普鲁士蓝色染色和ICP-OES证实了JMNP的细胞吸收.
- 细胞被用自由药物治疗,JMNP装载的药物,然后进行磁性高温 (43°C,AMF).
- 分析了细胞活力 (MTT测定) 和细胞亡/亡 (流细胞计).
主要成果:
- JMNPs有效地促进了癌细胞的药物吸收.
- 结合Qu/5-Fu/JMNPs和高热量,显著增加了ROS的产生.
- 综合治疗观察到细胞死亡和细胞死亡的协同增强.
结论:
- 作为有效的双重药物载体,JMNP对5-Fu和Quercetin起到作用.
- 基于JMNP的系统作为一种强大的热敏化剂,增强了高热效应.
- 这个平台展示了双模态协同作用的癌症治疗的巨大潜力.
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