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滴毒素的抗血管效应取决于ROS引起的RhoA/ROCK通路激活

Carlotta Boscaro1, Gudula Schimdt2, Andrea Cignarella1

  • 1Department of Medicine, University of Padova, Padova, Italy.

Biochemical pharmacology
|February 11, 2024
PubMed
概括

滴滴毒素通过激活RhoA通过活性氧物种 (ROS) 生产来抑制癌细胞迁移和血管生成,独立于FAK抑制. 这一途径涉及内皮NADPH氧化酶 (NOX) 和RhoA/ROCK信号级联.

关键词:
抗血管性药物 抗血管性药物心脏的葡萄糖化物.内皮细胞的迁移.在NADPH氧化酶.摇滚 摇滚 摇滚 摇滚这就是ROSOS ROS.在RhoA GTPase中.

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