在现场触发,浮动的传递系统的素长时间的胃保护
Konstantina Chachlioutaki1, Pedro H D M Prazeres2, Sérgio R A Scalzo2
1Department of Pharmacy Division of Pharmaceutical Technology, Aristotle University of Thessaloniki, Thessaloniki, Greece; Center for Interdisciplinary Research and Innovation (CIRI-AUTH), Thessaloniki, Greece.
概括
新的电膜有效地提供素治疗胃潰瘍. 这些胃浮膜提高药物溶解性,减少刺激,提供持续释放和抗炎作用.
科学领域:
- 材料科学 材料科学 材料科学
- 制药科学 制药科学
- 生物医学工程 生物医学工程
背景情况:
- 素 (CAP) 显示了胃肠的胃保护潜力,但面临着难以溶解性和高剂量刺激的挑战.
- 开发有效的药物输送系统对于克服口服素治疗的这些局限性至关重要.
研究的目的:
- 为了发展胃浮动,持续释放的电膜充满了素.
- 评估这些新膜的物理化学特性,药物释放,浮力,细胞相容性和抗炎作用.
主要方法:
- 使用Eudragit RL/RS聚合物和二碳酸 (SB) 作为泡剂,制备了电纳米纤维薄膜.
- 在模拟的胃液中评估了物理化学性质,浮力 (延迟时间,浮动时间) 和体外囊素释放.
- 细胞兼容性和抗炎效应在受脂聚糖 (LPS) 刺激的Caco-2细胞中进行了评估,测量了炎症性细胞因子和活性氧物种 (ROS).
主要成果:
- 无形薄膜表现出增强的湿透性,快速浮力 (<1s延迟时间) 和持续的浮力 (>24h).
- 持续释放的素被观察到长达24小时.
- 装有CAP的薄膜与Caco-2细胞具有生物相容性,并通过减少炎症标志物和ROS产生来表现出细胞保护作用.
结论:
- 胃浮动电膜为克服素的输送挑战提供了一个有希望的平台.
- 这项技术可实现持续的,胃特异性的药物输送,用于胃保护和潜在的其他治疗应用.
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