在艾滋病毒感染者中,COVID-19后的主要心血管事件
Raquel Martín-Iguacel1, Sergio Moreno-Fornés2, Andreu Bruguera3
1Centre of Epidemiological Studies of HIV/AIDS and STI of Catalonia (CEEISCAT), Health Department, Generalitat de Catalunya, Badalona, Spain; Department of Infectious Diseases, Odense University Hospital, Odense, Denmark.
COVID-19 感染显著增加了艾滋病毒感染者 (PWH) 患心血管事件的风险,在患病后的一年内,该风险增加了 30%. 这表明考虑COVID-19作为PWH的额外心血管疾病风险因素.
科学领域:
- 传染性疾病 传染性疾病
- 心脏病学 心脏病学
- 公共卫生 公共卫生
背景情况:
- 艾滋病毒感染者 (PWH) 可能对心血管事件 (CVEs) 具有独特的脆弱性.
- 在PWH中,COVID-19对心血管健康的影响尚未完全理解.
研究的目的:
- 评估COVID-19感染与艾滋病毒感染者 (PWH) 随后发生重大心血管事件 (CVEs) 的风险之间的关联.
主要方法:
- 基于人口的匹配队列研究使用加泰罗尼亚PISCIS艾滋病毒队列进行.
- 分析了COVID-19后首次CVE的发病率,使用竞争风险分析和逆概率权重进行调整.
- 包括4199名COVID-19的PWH和14004名没有COVID-19的PWH,随访时间中位数为243天.
主要成果:
- 与没有COVID-19的人相比,患有COVID-19的PWH在第一年显示出较高的CVE累积发病率 (日志排名p=0.011).
- COVID-19与随后的CVE风险增加30%有关 (调整后的危险比为1.30 [95% CI,1.09-1.55]).
- 这种增加的风险即使在没有先前心血管疾病 (CVD) 或没有因COVID-19住院治疗的人群中也存在.
结论:
- COVID-19感染与艾滋病毒感染者中重大心血管事件风险的短期显著增加有关.
- 临床医生应将COVID-19视为PWH中额外的心血管疾病风险因素.
- 进一步的研究可能有必要,以了解COVID-19在这个人群中对心血管的长期影响.
更多相关视频
05:53Measuring Frailty in HIV-infected Individuals. Identification of Frail Patients is the First Step to Amelioration and Reversal of Frailty
Published on: July 24, 2013
07:27Exergaming in Older People Living with HIV Improves Balance, Mobility and Ameliorates Some Aspects of Frailty
Published on: October 6, 2016
相关概念视频
Exercise and Cardiovascular Response
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
Ischemic Heart Disease: Overview
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
Psychoneuroimmunology: Cardiovascular Disease
A key area of focus in PNI is the relationship between stress and coronary...
Sexually Transmitted Infections
Cardiovascular Drugs: Classification based on Therapeutic Indications
Retrovirus Life Cycles
