不同河流中的抗生素耐药性基因和移动遗传元素:与抗生素,微生物群落和人类活动的联系
Lulu Zhang1, Haoda Chen1, Sai Gao1
1College of Environment Science and Engineering, Hebei University of Science and Technology, 050000 Shijiazhuang, Hebei Province, China.
The Science of the total environment
|February 11, 2024
概括
河流携带抗生素耐药性基因 (ARG),受移动遗传元素 (MGE) 和醇 (QN) 的影响. 人类活动和社会经济因素也影响了ARG在河流系统中的传播.
科学领域:
- 环境科学 环境科学
- 微生物学 微生物学
- 公共卫生 公共卫生
背景情况:
- 河流作为抗生素耐药性基因 (ARG) 的重要储库.
- 河流中ARG,微生物群落和流动基因元素 (MGE) 之间的相互作用尚未完全理解,特别是关于不同的抗生素水平和人类活动.
- 了解这些动态对于管理抗生素耐药性传播至关重要.
研究的目的:
- 在不同的人类影响水平的河流中调查ARG的时空分布和驱动力.
- 确定ARG,微生物群落,移动遗传元素 (MGE) 和环境因素,如抗生素度和社会经济因素 (SE) 之间的关系.
主要方法:
- 在两个城市河流 (UR),一个农村-城市河流 (RUR) 和两个农村河流 (RR) 中调查了ARG和MGE.
- 量化诺 (QN) 度和评估社会经济因素 (SE),如人口,GDP,污水和工业企业.
- 采用统计分析来确定MGEs,QNs,微生物群落和SEs对ARG丰度的相关性和影响.
主要成果:
- 与农村河流相比,城市河流的QN度显著更高,ARG和MGE的多样性更大.
- 在所有河流类型中,在MGEs和ARG之间观察到强烈的正相关性,在城市地区更明显的联系.
- 昆素 (QN) 和MGE直接增加了ARG的丰富性,而微生物群落则影响了城市和农村-城市河流中的ARG. 社会经济因素 (SE) 也发挥了重要作用,特别是在城市环境中.
结论:
- 移动遗传元素 (MGE) 和类素 (QN) 度是河流中抗生素耐药性基因 (ARG) 的关键驱动因素.
- 微生物群落和社会经济因素 (SE) 显著影响ARG的丰富性,特别是在城市化河流系统中.
- 有效的抗生素耐药性风险管理不仅需要考虑抗生素度,还需要考虑MGE和社会经济因素.
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