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基于西斯普拉丁的高温症内皮管内化疗中慢性病的危险因素
Chih-Chung Cheng1, Hung-Chieh Yeh2, Pei-Wen Su3
1Department of Surgery, China Medical University Hospital, Taichung, Taiwan.
概括
术内使用帕雷科克西布和在基于西斯的高热性腹腔内化疗 (HIPEC) 期间的高温显著增加了慢性病 (CKD) 的风险. 监测和控制这些因素对于HIPEC后更好的长期脏结果至关重要.
科学领域:
- 在瘤学瘤学.
- 腎臟病學 (nephrology) 是一種醫學.
- 手术瘤学手术瘤学
背景情况:
- 基于西斯普拉丁的高热性腹腔内化疗 (HIPEC) 是对腹腔内恶性瘤的标准治疗方法.
- 急性损伤 (AKI) 是HIPEC已知的并发症,但慢性病 (CKD) 在HIPEC后的理解较少.
- 这项研究调查了西斯-HIPEC后的CKD的发病率和风险因素.
研究的目的:
- 为了确定在基于西斯普拉丁的高温腹腔内化疗 (HIPEC) 后慢性病 (CKD) 的发生率.
- 为了确定与HIPEC后的CKD发展相关的风险因素.
- 在接受HIPEC治疗的患者中改善长期结局.
主要方法:
- 对55名接受了细胞减小手术 (CRS) 和基于的HIPEC的患者进行了回顾性分析.
- 患者被分为有CKD和没有CKD的组.
- 使用多变量回归分析来确定CKD的危险因素.
主要成果:
- 在55名患者中,43.6%患有AKI,其中70.8%进展为CKD.
- 在手术期间使用帕雷科克西布 (OR=4.39) 和最大手术期间温度>38.5°C (OR=6.40) 是CKD的重要风险因素.
- 虽然糖尿病和手术后并发症是AKI的危险因素,但它们对CKD发展没有显著意义.
结论:
- 在手术期间使用帕雷科克西布是西斯-HIPEC后CKD的重要危险因素.
- 维持手术期间的体温低于38.5°C可能会降低CKD风险.
- 识别和减轻这些风险因素对于在HIPEC患者中保持长期功能至关重要.
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