间歇性禁食和维生素E补充剂减轻了甲状腺功能低下症相关的眼科病变
Nirdesh Kumar1, Ashmita Das1, Nidhi Kumari1
1Department of Pharmacy, Guru Ghasidas Vishwavidyalaya (A Central University), Koni, Bilaspur, Chhattisgarh, 495009, India.
Molecular nutrition & food research
|February 11, 2024
概括
间歇性禁食和维生素E补充剂在预防与甲状腺功能低下相关的眼睛并发症方面表现有前途. 这些受阿育吠陀启发的疗法在实验模型中有助于减少甲状腺损伤和眼睛问题.
科学领域:
- 眼科医生 眼科 眼科
- 内分泌学 在内分泌学.
- 营养科学 营养科学
背景情况:
- 甲状腺功能低下症相关的眼病 (HAO) 包括各种眼睛疾病,如眼睛干燥,胀,视力模糊,绿内障和白内障.
- 目前,终身药物治疗是甲状腺功能低下症的唯一管理策略,没有可用的永久治疗方法.
- 需要有效的干预措施来缓解甲状腺功能低下症的眼部并发症.
研究的目的:
- 研究间歇性禁食 (IF) 和维生素E (Vit.E) 补充剂在预防甲状腺功能低下症相关的眼科病 (HAO) 的潜力.
- 评估IF和Vit.E在减少HAO进展方面的抗氧化潜力.
- 探索古代阿育吠陀的原则来管理甲状腺和眼睛的健康.
主要方法:
- 实验动物被分为五组:正常,甲状腺功能低下控制,双 (IF + Vit.E),仅Vit.E和仅IF.
- 甲状腺功能低下症被诱导使用propylthiouracil (PTU) 24天.
- 在相关组中,间歇性禁食和维生素E补充剂与PTU同时使用.
主要成果:
- 甲状腺功能低下诱导的动物表现出眼内压力 (IOP) 和脂质过氧化增加.
- 在甲状腺功能低下模型中,甲状腺激素水平显著下降,这表明甲状腺功能障碍对眼睛健康的影响.
- 结合IF和Vit.E治疗表明甲状腺和眼睛损伤的减少.
结论:
- 间歇性禁食和维生素E补充剂显示出潜在的预防策略来预防甲状腺功能低下症相关的眼科病.
- IF和Vit.E的抗氧化特性可能在减轻眼睛损伤方面发挥着至关重要的作用.
- 以阿尤尔韦达为灵感的疗法为管理甲状腺和眼睛健康提供了一个有希望的途径.
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