相关实验视频
Updated: Jul 3, 2025

10:04
Enhancing Tumor Content through Tumor Macrodissection
Published on: February 12, 2022
10.0K
扩散型大B细胞淋巴瘤的二线治疗:选择的演变
N Fabbri1, A Mussetti2, A Sureda3
1Department of Molecular Medicine, University of Pavia, Pavia, Italy.
Seminars in hematology
|February 11, 2024
概括
大多数扩散型大B细胞淋巴瘤患者对初始治疗有反应,但30%-40%的患者复发. 新的治疗方法为复发性/耐药性扩散性大B细胞淋巴瘤 (DLBCL) 患者提供了希望,特别是那些不符合移植或CAR T细胞疗法的患者.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
背景情况:
- 扩散性大B细胞淋巴瘤 (DLBCL) 是最常见的非霍奇金淋巴瘤.
- 虽然基于rituximab的化疗免疫疗法在60-70%的DLBCL患者中实现了缓解,但30%-40%的患者出现复发或耐药性疾病.
- 复发性/耐药性 (R/R) DLBCL 患者的重要部分面临着有限的治疗选择.
研究的目的:
- 审查R/R DLBCL不断变化的二线治疗场景.
- 要突出最近的治疗进步和R / R DLBCL管理的指导方针变化.
- 讨论那些无法接受标准疗法 (如自身干细胞移植或CAR T细胞疗法) 的患者的新疗法.
主要方法:
- 审查最近的临床试验数据和对R/R DLBCL疗法的监管批准.
- 对DLBCL复发和折射性的当前治疗指南的分析.
- 综合有关新药的信息,包括抗体与药物合物,免疫疗法和向药物的信息.
主要成果:
- 现在,二线治疗策略基于复发时间和患者接受移植或CAR T细胞治疗的资格而分层.
- 抗CD19CAR T细胞疗法最好用于高风险DLBCL (初级耐药或复发≤12个月).
- 新药物如波拉图祖马布维多丁,塔法西塔马布,隆卡斯图西马布特西林,塞林克索和双特异性抗体对移植不合格或CAR T细胞不合格的R/R DLBCL患者显示出希望.
结论:
- 对于R/R DLBCL的治疗算法已经显著进步,有了新的治疗选择.
- 新型药物为具有挑战性的R/R DLBCL患者群体提供了更好的疗效和可管理的安全性.
- 这些进展为复发性或耐药性疾病患者提供了新的希望和扩大了治疗选择.
相关概念视频
Targeted Cancer Therapies
7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.6K
Tumor Immunotherapy
524
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
524
Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
![Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F62334.jpg&w=3840&q=50)
