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在患者中,不对称的皮质表面积减少,具有后点通用电脑图抑制.

Chenyang Zhao1, Yingying Tang1, Yuan Xiao2

  • 1Department of Neurology, West China Hospital of Sichuan University, Chengdu 610041, Sichuan, China.

Cerebral cortex (New York, N.Y. : 1991)
|February 11, 2024
PubMed
概括
此摘要是机器生成的。

患有 postictal通用电脑抑制 (PGES) 患者的岛内皮层表面积减少,特别是在右侧. 这一发现表明大脑结构受损,并与中突然意外死亡的潜在联系.

关键词:
这就是为什么MRI是MRI.后切节性脑电图抑制 脑电图抑制在症中突然的意外死亡.表面积面积面积面积面积面积面积面积面积

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科学领域:

  • 神经成像是一种神经成像.
  • 发病学 (Epileptology) 是一个专业的学科.
  • 神经学 神经学

背景情况:

  • 静脉直通电脑抑制 (PGES) 是中突然意外死亡 (SUDEP) 的潜在标志物.
  • 调查皮质表面区域异常可能会阐明PGES的病理生理学.

研究的目的:

  • 为了研究与健康对照组相比,患有PGES和没有PGES的患者的皮质表面积差异.
  • 探索皮层表面积异常和临床变量之间的相关性.

主要方法:

  • 对30名PGES+患者,21名PGES-患者和30名健康对照患者的回顾性分析.
  • 基于高分辨率T1加权MRI扫描的表面分析,以比较皮质表面面积.
  • 与发作的年龄和其他相关的临床变量进行相关性分析.

主要成果:

  • 与PGES患者相比,PGES+患者的双边岛屿表面积减少,右侧占主导地位.
  • 减少右侧岛屿表面面积与较年轻的发作年龄相关.
  • 与对照人群相比,PGES患者的左尾中额头回表面积减少;与对照人群相比,PGES+患者在多个右半球和左半球区域的广泛减少.

结论:

  • 患有PGES的患者表现出皮质微结构性损伤,特别是在岛内皮质.
  • 在PGES+患者中右侧岛屿皮层表面积的减少表明自主网络的参与.
  • 这些发现表明潜在的共享异常大脑网络是PGES和SUDEP风险的基础.