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在重症COVID-19患者中估计疫苗接种的影响,使用倾向性得分匹配分析

Amarja Ashok Havaldar¹, Sumithra Selvam²

¹Department of Critical Care, St. John's Medical College Hospital, Bangalore, 560034, India. amarjahavaldar@rediffmail.com.

Annals of intensive care

|February 11, 2024

概括

接种COVID-19疫苗显著降低了重症监护室 (ICU) 死亡率的突破性感染的重症患者. 这项研究强调了疫苗接种.

科学领域:

关键护理医学关键护理医学
传染性疾病传染性疾病
疫苗学疫苗学疫苗学

背景情况:

接种COVID-19疫苗可以降低死亡率和疾病严重程度.
疫苗接种的个体可能会发生突破性感染.
疫苗接种对患有突破性感染的重症患者的影响需要进一步研究.

研究的目的:

评估COVID-19疫苗接种对重症监护室 (ICU) 临床病患死亡率的影响.
为了比较疫苗接种和未接种疫苗的COVID-19重病患者之间的死亡率.
分析疫苗接种对二次结果的影响,如ICU停留时间和机械通风持续时间.

主要方法:

追溯性研究包括2020年6月15日至2021年12月31日期间入院ICU的未接种疫苗和接种疫苗的COVID-19患者.
主要结局:ICU死亡率. 二次结果:在ICU停留的时间,机械通风的持续时间.
使用多变量逻辑回归 (MLR) 和倾向得分匹配 (PSM) 的统计分析.

主要成果:

总共包括841名患者:667名未接种疫苗 (79.31%) 和174名接种疫苗 (20.68%).
整体ICU死亡率为56.60%.
接种疫苗的患者显示死亡风险降低 (调整后几率比 (AOR) 0.52与MLR,0.83与PSM).

结论:

接种COVID-19疫苗有效地减少了重症患者的病例死亡率.
接种疫苗可以防止严重的后果,即使在突破性感染的情况下.
这些发现支持疫苗接种在减轻严重COVID-19的公共卫生重要性.

关键词:

突破性感染是一种突破性感染.在 COVID-19 疫情中,在ICU中,医生会对患者进行治疗.死亡率死亡率死亡率倾向性得分匹配的匹配方法未接种疫苗的人群疫苗接种疫苗接种

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