在脊髓中扩散的中线H3K27-改变的质瘤:一个系统的审查
Gina Watanabe1, Jennifer Manyu Wong1, Bradley Estes2
1John A. Burns School of Medicine, University of Hawai'i, Honolulu, HI, USA.
Journal of neuro-oncology
|February 11, 2024
概括
脊髓的扩散性中线质瘤 (DMG-SCs) 结果不佳,平均总生存时间为24个月. 然而,结果可能比内瘤更好,这表明DMG-SC预后可能异质.
科学领域:
- 神经瘤学神经瘤学
- 脊髓瘤 脊髓瘤 在线
- 分子病理学分子病理学
背景情况:
- 有H3K27变化的扩散中线质瘤 (DMG) 是一种具有攻击性的脑瘤.
- 脊髓干扰是一种独特的临床实体,数据有限.
- 了解DMG-SC特征对于改善患者的治疗结果至关重要.
研究的目的:
- 系统地审查脊髓扩散的中线H3K27改变的脊髓质瘤 (DMG-SCs) 的临床特征,管理策略和患者结果.
主要方法:
- 在PubMed,EMBASE,Scopus和Web of Science的综合文献搜索到2023年9月.
- 从39项研究中提取和分析患者人口统计数据,瘤特征,治疗数据和生存结果.
- 对收集的数据进行统计分析,以确定趋势和预后因素.
主要成果:
- 总共有279名患有DMG-SC的患者被分析,主要是男性 (61%),平均年龄为32岁.
- 常见的治疗方法包括联合手术,放射治疗和化疗 (31%) 或单独手术 (24%),次总切除频繁 (38%).
- 平均整体存活时间为24个月,平均无进展存活时间为14个月;然而,历史上的世卫组织4级DMG-SCs的存活率比2级或3级更差.
结论:
- DMG-SCs的整体存活率较低,但预后可能比内DMG更为有利.
- 2021年世界卫生组织将所有DMG分类为4级,需要进一步调查.
- DMG-SCs可能是一个异质的群体,需要进一步研究来定义不同的预后类别.
相关概念视频
02:32Histone Modification
The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...
02:25Spreading of Chromatin Modifications
The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
Writers
The writer is an enzyme that can...
Writers
The writer is an enzyme that can...
02:30Histone Variants at the Centromere
Histone variants are the histone proteins with structural and sequence variations. These variants may be regarded as “mutant” forms that replace their canonical histone counterparts in the nucleosomes. Specific post-translational modifications on the histone variants enable further chromatin complexity and regulate tissue-specific gene expression. The most common histone variants are from histone H2A, H2B, and linker histone H1 families. However, several variants of histone H3 variants are also...
02:32Histone Modification
The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...
Acetylation
The enzyme histone acetyltransferase adds acetyl group to the histones. Another enzyme, histone deacetylase,...