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在实验室医学中设置多变量参考区域的无分布的超矩形耐受区域.

Wei Liu1, Frank Bretz2, Mario Cortina-Borja3

  • 1Southampton Statistical Sciences Research Institute and School of Maths, University of Southampton, Southampton, SO17 1BJ, UK.

Statistics in medicine
|February 12, 2024
PubMed
概括

非参数的超矩形容忍区域提供了对实验室测试结果的可靠解释. 数学证明证实了它们对连续测量的有效性,提高了医学诊断的准确性.

关键词:
非参数公差区间的公差区间.非参数耐受性区域是一个非参数耐受性区域.参考范围范围的参考范围范围.参考区域是指参考地区的参考区域.这是一个宽容区间的宽容区间.耐受性区域是一个耐受区域.

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科学领域:

  • 统计 统计 统计 统计
  • 医学实验室科学 医学实验室科学
  • 生物统计学 生物统计学

背景情况:

  • 在实验室医学中,参考区域对于解释患者测试结果至关重要.
  • 通常使用的是耐受性区域,而超矩形区域对于多个结果测量特别有用.
  • 对于非参数的超矩形容忍区域的现有方法缺乏严格的数学验证.

研究的目的:

  • 开发和数学验证非参数的超矩形宽容区域.
  • 提供一种可靠的方法来构建适用于连续测量分布的公差区域.
  • 将验证的方法应用于真实世界的功能分析.

主要方法:

  • 使用Tukey的等价块来构建非参数的超矩形宽容区域.
  • 根据连续数据的假设,为这些容忍区域的有效性提供数学证明.
  • 应用构造区域来分析功能数据.

主要成果:

  • 使用Tukey的等效块构建了新的非参数的超矩形耐受区域.
  • 对于连续测量分布,这些容忍区域的数学有效性被严格证明.
  • 该方法已成功应用于分析功能,证明了其实用性.

结论:

  • 该研究提供了数学验证的非参数的超矩形耐受性区域.
  • 该方法提供了一种可靠和可解释的方法,用于建立实验室医学中的参考区域.
  • 这些发现对诊断测试的准确解释有重大意义,特别是那些具有多个结果测量的诊断测试.