电治疗对抑郁症皮质厚度的影响:一个系统性审查
Tommaso Toffanin1, Giulia Cattarinussi2,3,4, Niccolò Ghiotto2
1Department of Neuroscience and Rehabilitation, Institute of Psychiatry, University of Ferrara, Ferrara, Italy.
Acta neuropsychiatrica
|February 12, 2024
概括
电疗法 (ECT) 在抑郁症患者中增加皮质厚度 (CT),特别是在,岛屿和额头区域. 需要进一步的研究来确定这些CT变化是否与治疗有效性相关.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 放射学 放射学是一门学科.
背景情况:
- 电疗法 (ECT) 是一种成熟的严重抑郁症治疗方法.
- 电脑电阻的潜在神经机制,特别是结构性大脑变化,仍然在很大程度上未被探索.
研究的目的:
- 系统地审查结构磁共振成像 (sMRI) 关于在单极或双极抑郁症患者的ECT后纵向皮层厚度 (CT) 变化的研究.
- 综合有关脑部受ECT诱导CT改变影响的区域的发现,以及它们与临床结果的潜在相关性.
主要方法:
- 在PubMed,Medline和Embase数据库中进行了全面的文献搜索.
- 纳入标准集中在sMRI研究中,研究在抑郁人口中ECT后皮质厚度的变化.
- 总共有10项研究符合本系统性审查的纳入标准.
主要成果:
- 研究一致报告说,在ECT后,皮质厚度 (CT) 普遍增加.
- 受影响的大脑区域主要包括叶,岛叶和额叶.
- 五项研究表明,CT在特定大脑区域的增加与ECT的临床疗效相关.
结论:
- 在被诊断为单极和双极抑郁症的患者中,ECT的使用与皮质厚度增加有关.
- 在ECT诱导的CT变化和临床反应之间的关系需要进一步研究.
- 需要进行更大规模的,经过良好控制的,随访时间较长的研究,以确定CT作为ECT治疗反应的潜在生物标志物.
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