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生物启发的-交换 (SeNEx) 点击化学适合纳米分子规模的药物化学和生物结合

Wei Hou¹, Yiyuan Zhang², Fuchao Huang¹

¹College of Pharmaceutical Science and Institute of Drug Development & Chemical Biology, Zhejiang University of Technology, Hangzhou, 310014, China.

Angewandte Chemie (International ed. in English)

|February 12, 2024

概括

开发了一种新的-交换 (SeNEx) 点击反应,用于分子组装. 这种新的点击化学使得快速的功能发现和合成和生物结合的各种应用成为可能.

科学领域:

合成化学合成化学
化学生物学化学生物学
有机化学化学有机化学

背景情况:

点击化学对于快速分子组装和功能发现至关重要.
扩大点击化学工具箱需要新的反应与新的链接.
生物化学SeNEx反应为新的合成方法提供了灵感.

研究的目的:

要报告第一个-交换 (SeNEx) 点击反应.
建立一种新的点击反应,用于有机合成和生物结合.
为了证明SeNEx在各种化学应用中的多功能性.

主要方法:

开发一个SeNEx点击反应之间的benzoselenazolones和终端alkynes.
反应动力学,功能组兼容性和可扩展性的表征.
在序列点击化学,宏循环合成和生物结合中应用SeNEx.

主要成果:

在SeNEx点击反应中,形成具有高产量和快速动力学 (k2≥14.43 M−1s−1) 的单基因连接.
该反应表现出优异的功能组耐受性,并在纳米分子尺度上工作.
经过证明的应用包括顺序点击反应,瘤宏循环合成和蛋白质功能化.

结论:

SeNEx点击化学是对点击化学工具箱的一个有价值的补充.
这种新方法为有机合成和生物结合提供了一个变革性的平台.
SeNEx化学对合成化学,材料科学和药物发现有广泛的影响.

关键词:

-交易所 (SeNEx) 是一个-交易所.生物结合生物结合然后点击化学.纳米分子规模的并行合成.化的发生是因为化.

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