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全免疫性炎症价值与性结肠炎之间的关联
Aslıhan Mete Yıldırım1, Oğuzhan Yıldırım2
1Department of Medical Education, Inonu University, Malatya, Turkey.
Current medical research and opinion
|February 12, 2024
概括
在诊断时,性结肠炎患者的系统性炎症指数 (SII) 和泛免疫性炎症值 (PIV) 较高. 这些生物标志物与疾病严重程度相关,有助于了解性结肠炎的活动.
科学领域:
- 胃肠病学和肝病学
- 炎症性肠道疾病研究研究
- 生物标志物发现发现
背景情况:
- 性结肠炎 (UC) 是结肠和直肠的慢性炎症状况,其特点是复发和缓解疾病活动.
- 系统性炎症指数 (SII) 和泛免疫性炎症值 (PIV) 是新兴的生物标志物,在各种炎症和恶性疾病中具有潜在的应用.
- 现有的文献表明SII和PIV与其他炎症状况之间存在联系,但它们在UC活动中的特定作用需要进一步调查.
研究的目的:
- 研究系统性炎症指数 (SII) 和泛免疫性炎症值 (PIV) 与性结肠炎 (UC) 患者的疾病活性之间的关系.
- 评估SII和PIV作为性结肠炎的潜在诊断或预后标志物.
- 为了比较UC患者和健康对照者的SII和PIV水平.
主要方法:
- 在诊断时对146名性结肠炎患者进行了回顾性分析,包括临床,内镜和组织病理学数据.
- 计算和比较UC患者的系统性炎症指数 (SII) 和泛免疫性炎症值 (PIV) 水平与健康个体.
- 使用Mayo,Dublin和UCIES子记号对内镜疾病严重程度的评估;用于PIV切线的ROC曲线分析.
主要成果:
- 在性结肠炎患者和健康对照者之间观察到系统性炎症指数 (SII) 和泛免疫性炎症值 (PIV) 的统计学显著差异 (p < .001).
- 全免疫性炎症值 (PIV) 成为性结肠炎的独立预测因素 (OR: 1.157; p = .036).
- 在预测性结肠炎时,PIV的最佳切断值被确定为≥506,表明89.6%的灵敏度和63.7%的特异性 (AUC = 0.812).
结论:
- 在诊断时,性结肠炎患者的系统性炎症指数 (SII) 和泛免疫性炎症值 (PIV) 水平显著升高.
- 无论是SII还是PIV都与疾病严重程度有关,如内镜评分系统 (RACHMILEWITZ,UCEIS,DUBLIN) 所示,但不是MES评分.
- 作为预测性结肠炎和评估疾病活动的有价值生物标志物,PIV显示出希望.
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