在慢性鼻炎患者的上呼吸道和下呼吸道微生物组概况之间的比较
Juan Carlos Hernaiz-Leonardo1, Changwan Ryu2, Athenea Pascual1,2
1Division of Otolaryngology-Head and Neck Surgery, University of British Columbia, Vancouver, British Columbia, Canada.
International forum of allergy & rhinology
|February 12, 2024
概括
慢性鼻炎 (CRS) 患者的上呼吸道和下呼吸道微生物组是不同的. 细菌从鼻腔迁移到肺部在CRS中不太可能,这表明独特的气道环境.
科学领域:
- 微生物学 微生物学
- 肺部病理学 肺部病理学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 气道微生物群的失调与慢性鼻炎 (CRS) 和喘中的炎症有关.
- 上部 (鼻) 和下部 (肺) 气道微生物群之间的联系尚未得到充分理解.
研究的目的:
- 为了比较细菌微生物组的组成和CRS患者的鼻和下呼吸道之间的多样性.
- 调查CRS患者与并发性喘或没有并发性喘之间的气道微生物组概况的潜在差异.
主要方法:
- 从29名接受手术的CRS患者收集了鼻和支气管刷样本.
- 进行了用于微生物组分析的16S rRNA基因测序.
- 对比阿尔法和β多样性,并对配对样本之间的分类组合.
主要成果:
- 鼻腔样本的α多样性明显高于支气管样本.
- 在鼻腔和支气管微生物组之间观察到贝塔多样性和独特的微生物种群的显著差异.
- 患有喘的CRS患者与非喘CRS患者相比,表现出改变的鼻和支气管微生物概况.
结论:
- 在CRS患者中,鼻和支气管细菌群体显著不同.
- 证据不支持这种CRS队列中从上空气道向下空气道的显著细菌迁移.
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