血小板分布宽度与腹腔透析患者全因和心血管死亡率的关系

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Chunyu Lu¹, Shuiqin Cheng², Wenjing Fan²

¹Jinling Hospital Department of Nephrology, Nanjing Medical University, Nanjing, PR China.

|February 12, 2024

概括

血小板分布宽度 (PDW) 的升高是腹腔透析 (PD) 患者死亡率的重要预测因素. 在这个人群中,较高的PDW水平独立地与所有原因和心血管死亡率的风险增加有关.

科学领域:

腎臟病學 (nephrology) 是一種醫學.
心脏病学心脏病学
血液学血液学血液学

背景情况:

心血管疾病 (CVD) 对于接受腹腔透析 (PD) 的患者来说是一个重要的并发症.
血小板分布宽度 (PDW) 与血液透析 (HD) 患者的心血管事件有关.
关于PDW对PD患者死亡率的预测价值尚未完全阐明.

研究的目的:

为了研究血小板分布宽度 (PDW) 升高与腹腔透析 (PD) 患者全因和心血管死亡率之间的关联.
确定PDW是否可以作为PD患者死亡率的独立预测指标.

主要方法:

一项回顾性队列研究,在倾向性得分匹配 (PSM) 后,涉及426名PD患者.
接收器运行特征 (ROC) 曲线被用于确定PDW截止值.
考克斯的比例危险模型和限制立方线 (RCS) 分析被用来评估PDW和死亡率之间的关系.

主要成果:

经过对混因素进行调整后,PDW与全因死亡率 (HR = 1.162) 和心血管死亡率 (HR = 1.200) 的风险呈正相关性.
通过调整的RCS分析,PDW与所有原因和心血管死亡率之间的关系被发现是线性的.

结论:

血小板分布宽度升高 (PDW) 是患腹腔透析 (PD) 患者全因和心血管死亡的一个独立风险因素.
在PD患者的管理中,PDW可以作为一个有价值的预后生物标志物.

关键词:

血小板的分布宽度血小板的分布宽度所有原因的死亡率.心血管死亡率心血管死亡率腹膜透析是指腹膜透析.倾向性得分匹配的比分匹配

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