多关节炎的临床特征和结果:国际研究
Omer Karadag1, Ertugrul Cagri Bolek1, Gizem Ayan1
1Hacettepe University, Ankara, Turkey.
Arthritis & rheumatology (Hoboken, N.J.)
|February 12, 2024
概括
这项关于多关节炎 (PAN) 的国际研究揭示了常见的复发情况,并确定了系统性PAN (sPAN) 中死亡率的关键预测因素,包括老年和特定器官参与. 了解这些因素可以改善这种罕见的血管炎患者的治疗结果.
科学领域:
- 类风湿病学 类风湿病学
- 血管炎研究 血管炎研究
- 流行病学 流行病学
背景情况:
- 多关节炎 (PAN) 是一种罕见的全身性血管炎,具有多种临床表现.
- 有限的国际数据存在于PAN患者的综合人口统计,临床过程和生存结果.
研究的目的:
- 描述多关节炎 (PAN) 患者的人口统计,临床特征,疾病过程和生存率.
- 通过GLOBAL-PAN国际合作,通过系统性PAN (sPAN) 识别死亡率的预测因素.
主要方法:
- 对来自九个国家的观察队列中的358名PAN患者 (1990-2020年) 的回顾性分析.
- 符合欧洲药物局分类算法定义的资格;不包括与HBV相关的PAN和模仿单一性疾病.
- 收集有关器官参与,复发,损伤和生存的数据;进行统计分析.
主要成果:
- 该研究包括358名患者 (282名sPAN,76名皮肤PAN),诊断时平均年龄为44.3岁.
- 常见的表现包括体内症状 (71.5%),皮肤 (70.5%),肌肉骨 (69.1%) 和神经 (48.0%) 的特征.
- 48.5%的患者复发;sPAN的1,5年和10年生存率分别为97.1%,94.0%和89.0%. 在sPAN中死亡的预测因素包括年龄≥65岁,肌素>140μmol/L,胃肠道和中枢神经系统的参与.
结论:
- 多关节炎 (PAN) 是一种复杂的疾病,复发率很高.
- 年龄≥65岁,血清肌素升高,胃肠道或中枢神经系统的干扰是系统性PAN (sPAN) 中死亡率的独立预测因素.
- 这些发现强调需要对sPAN患者进行警监测和量身定制的管理策略.
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