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Allergic Reactions02:06

Allergic Reactions

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Overview
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Allergic Drug Reactions01:27

Allergic Drug Reactions

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Allergic reactions related to drugs are hypersensitivity responses driven by the immune system and bear no connection to the drug's therapeutic action. While drugs in isolation do not trigger an immune response, they can interact with endogenous proteins to form antigens. These antigens stimulate lymphocytes to produce antibodies. IgE-type antibodies attach themselves to mast cells. Upon subsequent exposure to the same stimulus, the antigen-antibody interaction is initiated, unleashing...
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Hypersensitivities01:30

Hypersensitivities

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Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
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Upper Respiratory Drugs: First and Second-Generation Antihistamines01:15

Upper Respiratory Drugs: First and Second-Generation Antihistamines

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Antihistamines are a class of drugs widely used to alleviate the symptoms of allergies, such as sneezing, itching, and nasal congestion. They work by inhibiting the actions of histamine, which is released by immune cells in response to allergenic substances or tissue injuries.
Histamine binds to specific receptor sites, known as H1 receptors, on tissue cells, triggering inflammation and swelling. Antihistamines combat these effects by competing with histamine for these receptor sites. By...
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Drugs Used in Lower Respiratory Disorders: Overview01:17

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Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
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Autoimmune Disorders01:29

Autoimmune Disorders

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
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相关实验视频

Updated: Jul 3, 2025

A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
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老年人的过敏性疾病

Gabriele Di Lorenzo1, Marcello Melluso2, Alessandro Rodolico3

  • 1Department of Health Promotion Sciences, Maternal and Infant Care, Internal Medicine and Medical Specialties (PROMISE), University of Palermo, Palermo, Italy.

Translational medicine @ UniSa
|February 12, 2024
PubMed
概括

过敏性疾病的增加与影响宿主微生物群的环境因素有关. 在老年人中,免疫和并发症通过改变免疫反应和促进炎症来加剧过敏.

关键词:
过敏性结膜炎是一种过敏性结膜炎.过敏性鼻炎是一种过敏性鼻炎.喘 喘 是一种年长的老人.免疫衰变的起源皮肤疾病 皮肤疾病

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科学领域:

  • 免疫学 免疫学 免疫学
  • 微生物学 微生物学
  • 老年学是指老年学的学科.
  • 环境健康 环境健康

背景情况:

  • 在全球范围内,过敏性疾病正在增加,受到卫生,饮食,污染和气候变化等影响宿主微生物群的因素的影响.
  • 老年人群因伴随疾病和与年龄相关的免疫系统变化 (免疫发生) 而出现过敏症的增加.
  • 主体微生物群在免疫调节,耐受性和对过敏原的反应中发挥着关键作用.

研究的目的:

  • 探索免疫衰变背后的机制及其对老年人过敏炎症的特定影响.
  • 了解如何改变微生物群的反应和炎症导致老年人过敏疾病.
  • 研究与衰老相关的免疫反应 (Th1到Th2) 的转变及其对过敏发展的影响.

主要方法:

  • 关于免疫衰变,微生物群和过敏性疾病的当前文献的综述.
  • 对免疫细胞功能的与年龄相关的变化和细胞因子概况的分析.
  • 在老年人群中检查伴随性疾病,微生物群和过敏反应之间的相互作用.

主要成果:

  • 免疫发生改变了微生物群的组成和功能,导致"炎症"并增加了对过敏的敏感性.
  • 在老年人中,从Th1到Th2免疫反应的转变有利于过敏反应.
  • 老年人的并发症可以进一步复杂化和加剧过敏的表现.

结论:

  • 了解免疫衰变及其对微生物群和免疫转移的影响,对于解决老年人过敏疾病至关重要.
  • 针对免疫和微生物群调节的机制,有望为老年人开发新的过敏疗法.
  • 需要进一步研究衰老,免疫力,微生物群和环境因素之间的复杂相互作用.