表观遗传年龄与危急病患者的结局的关联
Archana Sharma-Oates1, Jack Sullivan2,3, Daniel Pestana4
1School of Biosciences, University of Birmingham, Birmingham, United Kingdom.
Critical care explorations
|February 12, 2024
概括
表观遗传年龄加速,一个生物衰老的标志物,在患有败血症的重症患者和那些死亡的患者中显着更高. 这一发现表明表观遗传年龄可能预测败血症的结果.
科学领域:
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 老年学是一门学科.
- 关键护理医学 关键护理医学
背景情况:
- DNA甲基化模式可以表明生物年龄,反映了超越时间年龄的健康状况.
- 表观遗传年龄评估为了解严重疾病中的健康轨迹提供了一种新的方法.
研究的目的:
- 评估严重病情患者的表观遗传年龄,有或没有败血症.
- 为了确定加速表观遗传年龄是否与败血症诊断或患者死亡率相关.
主要方法:
- 来自嵌套病例对照研究中的DNA甲基化数据的二次分析.
- 利用来自加拿大四家三级医院的重症败血症和非败血症患者的全血样本.
- 采用Hannum和PhenoAge算法来计算表观遗传年龄和年龄加速.
主要成果:
- PhenoAge算法显示,与非败血症患者相比,败血症患者的表观遗传年龄显著加速 (4.97年) (p=0.045).
- 非幸存者在使用PhenoAge算法时,表现出比幸存者 (p=0.004) 更大的表观遗传年龄加速 (7.62年).
- 汉纳姆算法没有显示表观遗传年龄加速与败血症诊断或死亡率之间的显著关联.
结论:
- 表观遗传年龄加速,特别是通过PhenoAge测量,与重症患者的败血症诊断有关.
- 加快表观遗传年龄与重症患者死亡风险增加有关.
关键词:
通过DNA甲基化.生物年龄 生物年龄危急的疾病危急的疾病.遗传表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表观表这是一种血症.
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