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肠道微生物组及其治疗干预在心血管疾病中的作用
Ameer Luqman1,2, Adil Hassan1,2,3, Mehtab Ullah1
1Key Laboratory for Biorheological Science and Technology of Ministry of Education, State and Local Joint Engineering Laboratory for Vascular Implants, Bioengineering College of Chongqing University, Chongqing, China.
Frontiers in immunology
|February 12, 2024
概括
肠道微生物群影响心血管疾病 (CVD) 的风险. 肠道细菌及其代谢物的不平衡会导致动脉样硬化和高血压等疾病,提供新的治疗点.
科学领域:
- 微生物学 微生物学
- 心血管科学 心血管科学
- 代谢健康 代谢健康
背景情况:
- 肠道微生物群,一个复杂的微生物群落,对宿主健康至关重要.
- 肠道微生物的不平衡与慢性疾病有关,包括心血管疾病 (CVD),这是导致死亡的主要原因.
- 饮食,遗传和生活方式等因素显著影响肠道微生物组的组成和功能.
研究的目的:
- 审查肠道微生物群,其代谢物和心血管疾病发展之间的复杂关系.
- 要突出肠道失调如何加剧心血管疾病风险因素,如高血压和动脉样硬化.
- 探索针对肠道微生物组进行心血管疾病管理的治疗策略.
主要方法:
- 关于肠道微生物群和心血管疾病的现有证据的文献综述.
- 分析微生物代谢物 (如TMAO,SCFA) 在心血管健康中的作用.
- 检查治疗干预措施,包括益生菌,益生菌和便微生物群移植.
主要成果:
- 肠道微生物群失调与心血管疾病风险增加有关.
- 由肠道微生物群产生的微生物代谢物显著影响宿主代谢和心血管功能.
- 针对肠道微生物组的治疗干预措施在控制心血管疾病及其危险因素方面表现有前途.
结论:
- 肠道微生物群在心血管疾病的发病过程中起着至关重要的作用.
- 准肠道细菌及其代谢途径为心血管疾病预防和治疗提供了一种新的方法.
- 对肠道微生物群调节的进一步研究对于推进心血管医学至关重要.
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