与COVID-19相关的视网膜微血管病变和严重疾病患者的系统性影响:来自Methuselah研究的结果
Niccolò Castellino1, Antonio Longo1, Andrea Russo1
1Department of Ophthalmology, University of Catania, Catania, Italy.
Frontiers in medicine
|February 12, 2024
概括
在严重的COVID-19后视网膜微血管变化在12个月后是不可逆转的. 在COVID-19幸存者的这些持续变化与炎症,功能障碍和大动脉硬有关.
科学领域:
- 眼科医生 眼科 眼科
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
背景情况:
- 严重的COVID-19可能会导致长期的微血管变化.
- 这些视网膜变化的可逆性和系统性联系仍然不清楚.
研究的目的:
- 评估后COVID-19视网膜微血管变化的长期可逆性.
- 调查COVID-19幸存者的视网膜变化和其他血管疾病之间的关联.
主要方法:
- 涉及COVID-19患者和对照者的前性观察性研究.
- 对视网膜血管功能进行光学连贯性断层扫描血管学 (OCTA).
- 大动脉脉冲波速用于大动脉硬度,在出院1个月和12个月后进行评估.
主要成果:
- 1个月后,COVID-19患者表现出表面毛细管 (SCP) 血管密度降低和状血管区域扩大,在12个月后没有改善.
- 住院期间较高的炎症和较低的功能与大动脉硬和1个月后降低的SCP密度相关.
- 较慢的大动脉功能障碍恢复与12个月后视网膜血管结果较差有关.
结论:
- 在严重的COVID-19后12个月内,视网膜微血管变化仍然存在.
- 这些持续变化与医院内炎症,功能障碍和持续的大动脉硬有关.
相关概念视频
Glaucoma: Overview
1.7K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.7K
Diabetic Retinopathy
55
DefinitionDiabetic retinopathy is a microvascular complication of diabetes affecting the retinal blood vessels.Risk FactorsDiabetic retinopathy is present in almost all individuals with type 1 diabetes and more than 60% of those with type 2 diabetes after two decades of disease.The risk increases with poor glycemic control, hypertension, dyslipidemia, smoking, pregnancy, and puberty.Although cataracts and glaucoma are also more frequent in people with diabetes, retinopathy remains the leading...
55


