迪恩旋增强的血分离在自动驱动的螺旋微通道流与交叉流微过器
Yudong Wang1, Niladri Talukder1, Bharath Babu Nunna
1Advanced Energy Systems and Microdevices Laboratory, Department of Mechanical and Industrial Engineering, New Jersey Institute of Technology, Newark, New Jersey 07102, USA.
Biomicrofluidics
|February 12, 2024
概括
这项研究展示了一种无功耗的微流体装置,该装置使用惯性聚焦和迪恩效应来降低血液血位. 这项创新增强了血液血分离,用于临床诊断.
科学领域:
- 生物医学工程 生物医学工程
- 微流体学 微流体学
- 诊断设备 诊断设备 诊断设备
背景情况:
- 护理点 (POC) 诊断正在进步,但通常依赖于唾液,而不是血液.
- 对POC设备的血分离面临诸如细胞堵塞和高粘度等挑战,阻碍了效率.
- 目前的微过方法与高血红素血量作斗争,降低速度和有效性.
研究的目的:
- 为了研究全血的无功率微流体稀释方法.
- 为了提高血分离效率,用于POC诊断应用.
- 为了解决血液加工中微过的局限性.
主要方法:
- 实现了螺旋微通道设计,利用惯性聚焦和迪恩效应.
- 实验研究了毛细管流中的粒子惯性迁移.
- 在经过优化微通道的生理血红素值范围内测试全血样本.
主要成果:
- 在一个优化的350 × 60μm微通道中,达到最大88%的粒子迁移到平衡位置.
- 在优化的微通道中,在外部和内部分支出口之间显示出超过10%的血位降低.
- 在没有外部电源的情况下,在全血样本中成功降低了血红素.
结论:
- 开发的微流体装置有效地使用被动方法降低血液血位.
- 这种方法对在无功耗POC诊断系统中增强血分离有希望.
- 这些发现支持扩大基于血液的POC诊断.
相关概念视频
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