在HOME研究中评估PFAS混合物的纵向暴露与青少年心脏代谢风险之间的关联
Elvira S Fleury1, Jordan R Kuiper2, Jessie P Buckley3
1Department of Epidemiology, Brown University, Providence, RI.
Environmental epidemiology (Philadelphia, Pa.)
|February 12, 2024
概括
在童年期间暴露于和多基物质 (PFAS) 可能会对男性和女性的心脏代谢风险产生不同的影响. 较高的PFAS暴露与女孩的风险增加和男孩的风险降低有关,这表明性别特异性影响.
科学领域:
- 环境健康 环境健康
- 儿科健康 儿科健康
- 毒理学 毒理学 毒理学
背景情况:
- 儿童暴露于和多基基物质 (PFAS) 是一个越来越令人担忧的问题.
- 暴露于PFAS可能会影响长期的心脏代谢健康.
- 了解这些影响对于公共卫生干预至关重要.
研究的目的:
- 调查 PFAS 纵向暴露模式与儿童心脏代谢风险之间的关联.
- 在开发过程中识别不同的PFAS暴露档案.
- 检查PFAS暴露对心脏代谢结果的潜在性别特异性影响.
主要方法:
- 隐形形状分析在179名来自HOME研究的儿童中发现了两种PFAS暴露模式.
- 血清PFAS度从出生到12岁被测量.
- 心脏代谢风险因素,包括胰岛素耐药性,脂质比率,瘦素与阿迪波涅丁比率,血压,内脏脂肪和HbA1c在12岁时被评估.
主要成果:
- 在所有测量点上,一个个人资料显示PFAS总体暴露率更高.
- 虽然整体关联是零的,但儿童的性别显著改变了PFAS暴露和心脏代谢风险之间的关系.
- 暴露较高组的女性显示心脏代谢风险,血压和内脏脂肪增加;男性显示风险和内脏脂肪减少.
结论:
- 在儿童时期长期暴露于PFAS混合物可能对青少年心脏代谢风险产生性别特异性影响.
- 这些发现强调了在评估环境化学物质暴露对健康的影响时考虑性别的重要性.
- 需要进一步的研究来阐明这些性别特定关联背后的机制.
更多相关视频
10:31An Experimental Model of Diet-Induced Metabolic Syndrome in Rabbit: Methodological Considerations, Development, and Assessment
Published on: April 20, 2018
10.7K
11:31Rapid Fractionation and Isolation of Whole Blood Components in Samples Obtained from a Community-based Setting
Published on: November 30, 2015
16.1K
相关概念视频
Longitudinal Research
12.0K
Sometimes we want to see how people change over time, as in studies of human development and lifespan. When we test the same group of individuals repeatedly over an extended period of time, we are conducting longitudinal research. Longitudinal research is a research design in which data-gathering is administered repeatedly over an extended period of time. For example, we may survey a group of individuals about their dietary habits at age 20, retest them a decade later at age 30, and then again...
12.0K
Longitudinal Studies
161
Longitudinal studies are also widely used in other medical and social science fields. For instance, in cardiovascular research, they can monitor patients' health over decades to identify risk factors for heart disease, such as high cholesterol or smoking, and evaluate the long-term effectiveness of preventive measures. Similarly, in mental health studies, researchers might follow individuals from adolescence into adulthood to understand the development and progression of conditions like...
161
Psychoneuroimmunology: Cardiovascular Disease
30
Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
A key area of focus in PNI is the relationship between stress and coronary...
30
Introduction to Epidemiology
726
Epidemiology, known as the cornerstone of public health, involves studying the distribution and determinants of health-related events in defined populations and applying these insights to control health issues. This is essential for understanding how diseases spread, identifying populations at greater risk, and implementing measures to control or prevent outbreaks. Epidemiology addresses not only infectious diseases but also non-communicable conditions like cancer and cardiovascular disease,...
726
Relative Risk
171
Relative risk (RR) is a statistical measure commonly used in epidemiology to compare the likelihood of a particular event occurring between two groups. This metric is important for evaluating the relationship between exposure to a specific risk factor and the probability of a particular outcome. It plays a crucial role in medical research, public health studies, and risk assessment. Relative risk quantifies how much more (or less) likely an event is to occur in an exposed group compared to an...
171
