产前空气污染和学龄前儿童认知功能的敏感发育窗口 墨西哥儿童
Hsiao-Hsien Leon Hsu1,2, Jamil M Lane1, Lourdes Schnaas3
1Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, New York.
Environmental epidemiology (Philadelphia, Pa.)
|February 12, 2024
概括
产前暴露于细颗粒物 (PM2.5) 与儿童的认知评分较低有关,特别是在怀孕晚期. 识别敏感的窗户是了解污染的关键.
科学领域:
- 环境健康 环境健康
- 神经科学是一个神经科学.
- 发育儿科 发育儿科
背景情况:
- 空气污染,特别是细颗粒物 (PM2.5) 构成神经毒性的风险越来越大.
- 产前暴露于PM2.5的时间可能会显著影响神经发育结果.
- 了解敏感的暴露窗口对于减轻与污染相关的神经发育障碍至关重要.
研究的目的:
- 调查产前暴露于细颗粒物 (PM2.5) 和儿童认知功能之间的关联.
- 在怀孕期间识别特定的敏感窗口,当PM2.5暴露可能影响神经发育时.
- 使用先进的统计方法,精确识别暴露与结果关系.
主要方法:
- 分析了553个满期婴儿的出生队列.
- 产前PM2.5暴露被估计使用一个经过验证的基于卫星的时空模型.
- 在4-5岁时使用麦卡锡儿童能力尺度 (MSCA) 评估认知功能,使用贝叶斯分布式滞后相互作用模型来确定易感窗口.
主要成果:
- 增加的PM2.5暴露与妊娠31-35周的更低的一般认知指数得分显著相关.
- 减少的定量和运动尺度得分与怀孕30-36周的PM2.5暴露有关.
- 较低的口头评分与怀孕37-38周的PM2.5暴露有关,这表明怀孕后期的脆弱性至关重要.
结论:
- 产前PM2.5暴露,特别是在怀孕晚期,与儿童的各种认知子表相反相关.
- 数据驱动的敏感暴露窗口的识别提供了对空气污染引起的神经发育障碍机制的宝贵见解.
- 这些发现强调了在关键的产前期减少PM2.5暴露的重要性,以保护儿童的认知发展.
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