在依赖吗啡的老鼠中,基于价值的决策受损部分与前带皮层和底侧杏仁体之间的神经连接有关
Zahra Fatahi1, Mohammad Fatahi2, Abbas Haghparast1,3,4
1Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, School of Medicine, Tehran, Iran.
EXCLI journal
|February 12, 2024
概括
底侧杏仁体 (BLA) 和前带皮层 (ACC) 之间的神经同步对于基于努力的决策至关重要. 吗啡依赖会改变这种BLA-ACC连贯性,影响寻求奖励的行为.
科学领域:
- 神经科学是一个神经科学.
- 决策研究 决策研究
- 成研究研究成研究.
背景情况:
- 底侧杏仁体 (BLA) 在决策过程中发挥着关键作用.
- 了解基于努力的选择背后的神经机制至关重要,特别是在物质依赖的背景下.
研究的目的:
- 在努力选择决策过程中调查BLA和前带带皮层 (ACC) 之间的功能和神经同步.
- 为了比较这些神经动态在前吗啡依赖与吗啡依赖状态.
主要方法:
- 采用了T迷宫任务,不同的努力 (大与小) 和奖励 (大与小).
- 当地现场潜力从BLA和ACC同时记录.
- 神经同步 (连贯性) 在不同频段 (三角形,三角形,β,马) 进行了分析.
主要成果:
- 在前吗啡依赖中,在高回报/高精力选择的β和马频段发生了显著的BLA-ACC同步,并在精力支出期间跨越delta,theta,β和马频段.
- 在吗啡依赖中,神经连贯性减弱,特别是在低回报/低精力选择和低精力支出期间的马频段.
- 在获得奖励期间的同步不同,与依赖吗啡的老鼠相比,与依赖吗啡前的老鼠相比,对于依赖吗啡的老鼠的低奖励,beta和gamma频段的连贯性降低.
结论:
- BLA和ACC之间的功能和神经连贯性是基于努力的决策和努力的基础.
- 吗啡依赖与改变的BLA-ACC神经连贯性有关,这可能解释了向低回报/低努力偏好和减少努力支出的转变.
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