超越传统指标:一种用于测量双相情绪障碍情绪不稳定的新方法
Sarah Sperry1, Anastasia Yocum1, Melvin McInnis1
1University of Michigan.
Research square
|February 12, 2024
概括
情绪不稳定,通过患者报告的结果来衡量,有效地将双相情感障碍 (BD) 与其他疾病区分开来,并预测功能结果. 这表明BD监控的新标准.
科学领域:
- 精神病学和心理健康 精神病学和心理健康
- 纵向队列研究 纵向队列研究
- 患者报告的结果
背景情况:
- 目前的双相情感障碍 (BD) 护理重点是情节缓解,使用症状严重程度作为主要结果.
- 需要具有临床实用性的新型结果措施,以按情绪不稳定性对BD患者进行分层.
研究的目的:
- 通过量化情绪不稳定来引入一种新的方法来测量双相情绪障碍 (BD) 的结果.
- 评估情绪不稳定的临床实用性作为结果指标,以及其对BD个体分层的能力.
主要方法:
- 在一项为期10年的纵向队列研究中,利用了603名参与者的数据 (385名有BD).
- 计算情绪不稳定性作为患者报告的抑郁, (低) 躁狂和焦虑结果 (PROMs) 的个人内部变异.
- 参与者分为低,中等和高情绪不稳定值.
主要成果:
- 与精神病和健康对照人群相比,患有BD的个人在抑郁症, (低) 躁狂和焦虑中表现出明显更高的情绪不稳定性.
- 与对照组相比,更多的BD患者陷入了中度和高的不稳定值.
- 更高的情绪不稳定值显著预测了更差的健康功能.
结论:
- 来自PROMs的情绪不稳定性,有效地描述了BD疾病的过程,并与功能结果相关联.
- 这一措施显著地使BD患者与对照患者区别开来,支持其在临床试验中的使用.
- 结果主张在BD结果监测中进行范式转变,强调情绪不稳定性作为主要指数.
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