性行为对HIV-1血清转换的影响是由肠道微生物群和促炎细胞因子调解的
Huang Lin1,2, Yue Chen1,3, Grace Abror4
1Co-first authors.
Research square
|February 12, 2024
概括
肠道微生物群的变化调解了高风险性行为与男性HIV-1血清转化之间的联系. 失生症的特征是细菌组成的改变,预测未来的艾滋病毒感染,建议微生物干预预防.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 确立了HIV-1血清转化和肠道失调症之间的联系,以及与性活动的关联.
- 肠道失调症在高风险性行为对HIV-1血清转换的影响中介作用尚不清楚.
研究的目的:
- 调查肠道失生症是否介导高风险性行为对男性HIV-1血清转换的影响.
- 确定与高风险性行为和HIV-1血清转化相关的特定肠道微生物和炎症变化.
主要方法:
- 专注于与多个伴侣进行接受性交的男性.
- 分析了肠道微生物组成的变化,促炎性细胞因子 (sCD14,sCD163),以及它们与性行为和HIV-1血清转换的相关性.
- 使用调解分析来确定因果关系的途径.
主要成果:
- 高风险的性行为导致了显著的肠道微生物变化,包括有益细菌减少和促炎性物种增加.
- 这些微生物变化,以及细胞因子的升高,在血清转化之前就观察到,并且与性伴侣数量相关.
- 随着剂量依赖,共生细菌之间的相关性减少也与增加的性伴侣有关.
结论:
- 促炎性细胞因子和肠道微生物群调解高风险性行为的对HIV-1血清转换的影响.
- 在血清转换剂中观察到的肠道微生物变化表明了因果作用.
- 准肠道微生物群为高风险个体的艾滋病毒预防干预提供了潜在的战略.
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