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分析单核酸多态对hnnRNPA2/B1蛋白质稳定性和功能的影响:针对抗癌治疗设计的见解

Kunal Dutta1, Viacheslav Kravtsov1, Katerina Oleynikova2

  • 1Infochemistry Scientific Center, ITMO University, Lomonosova str. 9, St. Petersburg 191002, Russian Federation.

ACS omega
|February 12, 2024
PubMed
概括

在 hnRNPA2/B1 蛋白质中,有两种常见的遗传变异,F66L 和 E92K,降低了它的稳定性. 该E92K变种与癌症突变增加有关,影响RNA处理和潜在的抗癌药物开发.

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