高血清 Askorbic 酸水平与美国成年人抑郁症患病率较低有关:一个病例对照研究
Mengyuan Chen1,2, Haolong Luo1,2, Yan Han1,2
1Department of Nutrition, School of Public Health, Xuzhou Medical University, Xuzhou, China.
Frontiers in nutrition
|February 12, 2024
概括
高血清 Askorbic 酸水平与美国成年人抑郁症的发病率较低有关. 这项研究强调了维生素C状态在心理健康中的重要性,解决了以前饮食摄入研究的局限性.
科学领域:
- 营养科学 营养科学
- 精神病学是一个精神病学.
- 流行病学 流行病学
背景情况:
- 以前的研究表明,酸摄入量与抑郁症之间存在联系,但受到回忆偏差和忽视的吸收差异的限制.
- 亚酸 (维生素C) 在神经递质合成和抗氧化剂防御中起着至关重要的作用,可能影响情绪调节.
研究的目的:
- 在美国成年人代表性样本中调查血清 Askorbic 酸水平与抑郁症患病率之间的关联.
- 通过检查客观血清水平而不是自我报告的饮食摄入量来解决先前研究的局限性.
主要方法:
- 利用了2017-2018年国家健康和营养检查调查 (NHANES) 3,404名参与者的数据.
- 员工倾向分数匹配 (PSM) 来创建一个病例对照研究 (299例抑郁症病例,1107例对照).
- 使用二进制逻辑回归和限制立方 (RCS) 分析数据,以评估血清 Askorbic 酸和抑郁症患病率之间的关系.
主要成果:
- 抑郁症的患病率为8.8%,抑郁症患者的血清 Askorbic 酸水平 (42.97 μmol/L) 与非抑郁症患者 (52.97 μmol/L) 相比显著降低.
- 观察到一种剂量与反应的关系:血清 Askorbic 酸水平的四分位数增加与抑郁症患病率的降低相关 (Q1:12.0%到Q4:5.4%).
- 较高的血清亚酸水平 (Q4与Q1) 与抑郁症的几率比率降低有关 (OR=0.42,调整后OR=0.49),具有统计学意义的L形非线性关联.
结论:
- 较高的血清 Askorbic 酸水平与美国成年人抑郁症的发病率降低显著相关.
- 对血清 Askorbic 酸的客观测量提供了更可靠的维生素 C 状态与抑郁风险相关的指标,而不是饮食回忆.
- 这些发现强调了维护足够的维生素C水平对心理健康和预防抑郁症的潜在作用.
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