血清蛋白质组分析揭示了带有鼻息肉病理生理学的异性慢性鼻炎的生物标志物
Yu Chen1, Ru Gao1, Honghui Liu1
1Department of Otolaryngology-Head and Neck Surgery, the Third Xiangya Hospital, Central South University, Changsha, Hunan, People's Republic of China.
Journal of inflammation research
|February 12, 2024
概括
像MMP2这样的血清生物标志物可以帮助区分异性慢性鼻炎与鼻 (eCRSwNP) 与其他形式. 升高的MMP2水平与组织色素相关,为疾病病理生理学提供了洞察力.
科学领域:
- 免疫学 免疫学 免疫学
- 蛋白质组学是指蛋白质组学.
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
背景情况:
- 带有鼻的eosinophilic慢性鼻炎 (eCRSwNP) 与较差的结果和更高的复发率有关.
- 早期区分CcRSwNP对于有效管理和理解其潜在机制至关重要.
研究的目的:
- 为了确定血清蛋白生物标记物,以便早期区分eCRSwNP.
- 调查已识别的生物标志物与CcRSwNP.NP的病理生理学之间的关系.
主要方法:
- 血清蛋白质组学被用于发现队列,以确定CCRSwNP和非eosinophilic CRSwNP (neCRSwNP) 之间的差异表达蛋白质.
- 候选蛋白质在一个独立的队列中使用ELISA,西部斑点,qRT-PCR和免疫光检测进行了验证.
- 评估了预测值和与组织色素友爱相关的相关性.
主要成果:
- 确定了39种不同表达的蛋白质;在CcRSwNP中,有20种是上调的,19种是下调的.
- 在CcRSwNP患者中,MRC1,CDH13和MMP2的血清水平显著更高.
- MMP2和MRC1对eCRSwNP显示出有前途的预测值,并且在组织中被上调,MMP2主要位于乙酸细胞上.
结论:
- 蛋白质组分析发现循环蛋白质是eCRSwNP的潜在手术前生物标志物.
- 在eCRSwNP中血清MMP2水平的升高与组织异osinophilia相关,为疾病病理生理学提供了洞察力.
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