高的手术前系统性免疫炎症指数值显著预测了在冠状动脉绕道手术后的糟糕结果
I Made Adi Parmana1, Cindy Elfira Boom1, Herdono Poernomo1
1Department of Anesthesiology and Intensive Care, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia.
Journal of inflammation research
|February 12, 2024
概括
一个高的手术前系统性免疫炎症指数 (SII) 预测在接受冠状动脉旁路移植 (CABG) 手术的患者中增加并发症和死亡率. 这一发现有助于对心脏手术患者的风险分层.
科学领域:
- 心血管外科心血管外科
- 免疫学 免疫学 免疫学
- 关键护理医学 关键护理医学
背景情况:
- 在冠状动脉旁路移植 (CABG) 是冠状动脉疾病 (CAD) 的标准治疗方法.
- 在式CABG中使用的心肺旁路可以触发全身炎症反应,增加发病和死亡风险.
- 确定不良结果的预测标记对于优化患者管理至关重要.
研究的目的:
- 评估手术前系统性免疫炎症指数 (SII) 与在 CABG 患者的术后结果之间的关联.
- 确定SII是否可以作为在内CABG后并发症和死亡率的预测标记.
主要方法:
- 一项对1056名在2019年1月至2022年12月期间接受 CABG 患者的回顾性研究.
- 术前的淋巴细胞,中性粒细胞和血小板计数被用来计算SII.
- 为了进行比较分析,患者根据SII截止值为528.715 × 103/mm3的值被分为两组.
主要成果:
- 在46%的患者中观察到高的手术前SII (≥528.715 × 103/mm3).
- 高SII与延长手术持续时间,心肺绕道时间,机械呼吸,ICU住院和住院显著相关.
- 升高的SII独立预测了术后心房动,心脏骤停,急性心肌梗塞和死亡率的风险增加.
结论:
- 手术前的SII是接受式CABG的患者手术前不良结果的重要预测因素.
- 较高的SII水平表明患病率和死亡率的风险较高,这表明其在风险分层和患者管理策略中的有用性.
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